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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC6 All Species: 13.33
Human Site: Y485 Identified Species: 24.44
UniProt: Q9UBN7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBN7 NP_006035.2 1215 131419 Y485 Q S R T G L V Y D Q N M M N H
Chimpanzee Pan troglodytes XP_515218 669 71461
Rhesus Macaque Macaca mulatta XP_001101619 1229 132810 Y499 Q S R T G L V Y D Q S M M N H
Dog Lupus familis XP_855362 1212 132670 E528 E E K A E K E E E R P W Q P S
Cat Felis silvestris
Mouse Mus musculus Q9Z2V5 1149 125685 Y484 Q N R T G L V Y D E K M M S H
Rat Rattus norvegicus Q569C4 588 63939
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519396 803 87971 Y139 Q R E R M D G Y C M F N H L A
Chicken Gallus gallus
Frog Xenopus laevis NP_001080486 1286 140963 Y486 E Q R T A L V Y D E Q M M E H
Zebra Danio Brachydanio rerio XP_693858 858 93375 T194 P F W K S L Q T F E G G P L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121726 1019 114505 G355 A A L G C P E G E M L I T P A
Nematode Worm Caenorhab. elegans Q20296 955 106730 G291 G M C L T P D G Y S H I L Y H
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX28 660 72704
Baker's Yeast Sacchar. cerevisiae P53973 706 80051 V42 T S K S K R Q V I V P V C M P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.4 97.4 80.6 N.A. 73.9 26.4 N.A. 41.8 N.A. 46.8 38.1 N.A. N.A. 35.7 33.1 N.A.
Protein Similarity: 100 39 97.9 85.5 N.A. 80.5 35.5 N.A. 51.1 N.A. 62.6 49.8 N.A. N.A. 53.1 48 N.A.
P-Site Identity: 100 0 93.3 0 N.A. 73.3 0 N.A. 13.3 N.A. 60 6.6 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 100 0 100 26.6 N.A. 93.3 0 N.A. 13.3 N.A. 73.3 13.3 N.A. N.A. 20 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. 33.9 33.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 8 0 0 0 0 0 0 0 0 0 16 % A
% Cys: 0 0 8 0 8 0 0 0 8 0 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 8 8 0 31 0 0 0 0 0 0 % D
% Glu: 16 8 8 0 8 0 16 8 16 24 0 0 0 8 0 % E
% Phe: 0 8 0 0 0 0 0 0 8 0 8 0 0 0 0 % F
% Gly: 8 0 0 8 24 0 8 16 0 0 8 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 39 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 16 0 0 0 % I
% Lys: 0 0 16 8 8 8 0 0 0 0 8 0 0 0 0 % K
% Leu: 0 0 8 8 0 39 0 0 0 0 8 0 8 16 0 % L
% Met: 0 8 0 0 8 0 0 0 0 16 0 31 31 8 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 8 8 0 16 0 % N
% Pro: 8 0 0 0 0 16 0 0 0 0 16 0 8 16 8 % P
% Gln: 31 8 0 0 0 0 16 0 0 16 8 0 8 0 0 % Q
% Arg: 0 8 31 8 0 8 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 24 0 8 8 0 0 0 0 8 8 0 0 8 16 % S
% Thr: 8 0 0 31 8 0 0 8 0 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 31 8 0 8 0 8 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 39 8 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _