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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
10
Human Site:
Y544
Identified Species:
18.33
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
Y544
L
T
C
H
S
A
E
Y
V
G
H
L
R
A
T
Chimpanzee
Pan troglodytes
XP_515218
669
71461
A52
Q
R
C
L
R
L
S
A
R
E
A
S
E
E
E
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
Y558
L
T
C
H
S
A
E
Y
V
G
H
L
R
A
T
Dog
Lupus familis
XP_855362
1212
132670
V575
H
P
E
M
P
Q
R
V
F
R
I
M
R
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
L531
I
L
P
A
R
P
A
L
G
S
E
L
L
T
C
Rat
Rattus norvegicus
Q569C4
588
63939
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
Y186
D
Q
D
S
S
V
L
Y
F
S
I
H
R
Y
E
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
Y545
Q
M
C
H
S
L
S
Y
I
Q
K
I
E
A
S
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
P241
N
M
W
D
S
H
H
P
E
L
P
Q
R
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
T402
S
A
A
L
T
L
R
T
L
L
S
D
P
C
P
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
S338
L
L
G
Y
A
P
F
S
I
E
L
N
E
A
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
G43
C
K
H
D
T
P
D
G
E
D
H
P
E
C
P
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
R89
P
H
P
E
D
P
R
R
I
Y
R
I
Y
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
6.6
100
6.6
N.A.
6.6
0
N.A.
20
N.A.
33.3
13.3
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
100
6.6
100
13.3
N.A.
13.3
0
N.A.
20
N.A.
53.3
20
N.A.
N.A.
13.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
16
8
8
0
0
8
0
0
31
0
% A
% Cys:
8
0
31
0
0
0
0
0
0
0
0
0
0
16
8
% C
% Asp:
8
0
8
16
8
0
8
0
0
8
0
8
0
0
0
% D
% Glu:
0
0
8
8
0
0
16
0
16
16
8
0
31
8
16
% E
% Phe:
0
0
0
0
0
0
8
0
16
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
8
8
16
0
0
0
0
0
% G
% His:
8
8
8
24
0
8
8
0
0
0
24
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
24
0
16
16
0
8
8
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
8
0
0
8
0
% K
% Leu:
24
16
0
16
0
24
8
8
8
16
8
24
8
0
8
% L
% Met:
0
16
0
8
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
8
8
16
0
8
31
0
8
0
0
8
8
8
0
24
% P
% Gln:
16
8
0
0
0
8
0
0
0
8
0
8
0
0
0
% Q
% Arg:
0
8
0
0
16
0
24
8
8
8
8
0
39
8
0
% R
% Ser:
8
0
0
8
39
0
16
8
0
16
8
8
0
0
16
% S
% Thr:
0
16
0
0
16
0
0
8
0
0
0
0
0
8
16
% T
% Val:
0
0
0
0
0
8
0
8
16
0
0
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
31
0
8
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _