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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
9.09
Human Site:
Y674
Identified Species:
16.67
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
Y674
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
Chimpanzee
Pan troglodytes
XP_515218
669
71461
L163
H
A
K
Q
K
H
G
L
H
R
I
L
V
V
D
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
Y688
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
Dog
Lupus familis
XP_855362
1212
132670
C686
H
A
E
R
D
A
A
C
G
F
C
F
F
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
I642
I
A
G
R
A
L
R
I
L
I
V
D
W
D
V
Rat
Rattus norvegicus
Q569C4
588
63939
E82
T
Q
T
L
D
K
E
E
L
H
T
L
S
K
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
T297
R
P
P
P
L
A
R
T
G
L
V
Y
D
P
T
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
Y678
L
Y
M
S
L
H
R
Y
D
E
G
L
F
F
P
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
A352
V
R
P
P
G
H
H
A
E
K
D
T
A
C
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
G513
D
R
S
F
V
Q
Q
G
R
S
A
T
K
E
E
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
K449
E
E
D
N
H
P
E
K
P
A
R
T
R
R
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
P154
C
G
F
A
I
V
R
P
P
G
H
H
A
E
A
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
V200
V
K
N
S
L
A
V
V
R
P
P
G
H
H
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
6.6
100
6.6
N.A.
6.6
6.6
N.A.
13.3
N.A.
80
13.3
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
100
6.6
100
6.6
N.A.
20
6.6
N.A.
13.3
N.A.
86.6
26.6
N.A.
N.A.
20
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
8
8
24
8
8
0
8
8
0
16
0
16
% A
% Cys:
8
0
0
0
0
0
0
8
0
0
8
0
0
8
0
% C
% Asp:
8
0
8
0
16
0
0
0
24
0
8
8
8
8
8
% D
% Glu:
8
8
8
0
0
0
16
8
8
8
0
0
0
16
8
% E
% Phe:
0
0
8
8
0
0
0
0
0
8
0
8
31
24
0
% F
% Gly:
0
8
8
0
8
0
8
8
16
8
24
8
0
0
8
% G
% His:
16
0
0
0
8
39
8
0
8
24
8
8
8
8
0
% H
% Ile:
8
0
0
0
8
0
0
8
0
8
8
0
0
0
8
% I
% Lys:
0
8
8
0
8
8
0
8
0
8
0
0
8
8
0
% K
% Leu:
24
0
0
8
39
8
0
8
16
8
0
24
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
8
16
16
0
8
0
8
16
8
8
0
0
8
24
% P
% Gln:
0
8
0
8
0
8
8
0
0
0
0
0
0
0
8
% Q
% Arg:
8
16
0
16
0
0
47
0
16
8
8
0
8
8
0
% R
% Ser:
0
0
8
31
0
0
0
0
0
8
0
0
8
0
8
% S
% Thr:
8
0
8
0
0
0
0
8
0
0
8
39
0
0
8
% T
% Val:
16
0
16
0
8
8
8
8
0
0
16
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
24
0
0
0
0
0
24
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _