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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC6 All Species: 8.18
Human Site: Y715 Identified Species: 15
UniProt: Q9UBN7 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBN7 NP_006035.2 1215 131419 Y715 P R M G D A D Y L A A W H R L
Chimpanzee Pan troglodytes XP_515218 669 71461 P204 Y E H G R F W P F L R E S D A
Rhesus Macaque Macaca mulatta XP_001101619 1229 132810 Y729 P R M G D A D Y L A A W H R L
Dog Lupus familis XP_855362 1212 132670 I727 H G N G T Q H I F E E D P S V
Cat Felis silvestris
Mouse Mus musculus Q9Z2V5 1149 125685 D683 G T F F P M G D E G A S S Q V
Rat Rattus norvegicus Q569C4 588 63939 H123 A V L T G A V H N G V A L V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519396 803 87971 R338 A E L G L T Q R C R A L P A R
Chicken Gallus gallus
Frog Xenopus laevis NP_001080486 1286 140963 Y719 G K M G D V E Y L M A F H R V
Zebra Danio Brachydanio rerio XP_693858 858 93375 G393 V D W D V H H G N G T Q H I F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121726 1019 114505 V554 Q A E T Y N S V Y L H P E T W
Nematode Worm Caenorhab. elegans Q20296 955 106730 K490 I R L V H T K K M L E H L R T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX28 660 72704 V195 G V K K I L I V D W D V H H G
Baker's Yeast Sacchar. cerevisiae P53973 706 80051 I241 E S V R R I M I L D W D I H H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.4 97.4 80.6 N.A. 73.9 26.4 N.A. 41.8 N.A. 46.8 38.1 N.A. N.A. 35.7 33.1 N.A.
Protein Similarity: 100 39 97.9 85.5 N.A. 80.5 35.5 N.A. 51.1 N.A. 62.6 49.8 N.A. N.A. 53.1 48 N.A.
P-Site Identity: 100 6.6 100 6.6 N.A. 6.6 6.6 N.A. 13.3 N.A. 53.3 6.6 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 100 6.6 100 13.3 N.A. 20 20 N.A. 20 N.A. 80 6.6 N.A. N.A. 0 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. 33.9 33.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 0 24 0 0 0 16 39 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 8 0 8 24 0 16 8 8 8 8 16 0 8 0 % D
% Glu: 8 16 8 0 0 0 8 0 8 8 16 8 8 0 0 % E
% Phe: 0 0 8 8 0 8 0 0 16 0 0 8 0 0 8 % F
% Gly: 24 8 0 47 8 0 8 8 0 24 0 0 0 0 8 % G
% His: 8 0 8 0 8 8 16 8 0 0 8 8 39 16 8 % H
% Ile: 8 0 0 0 8 8 8 16 0 0 0 0 8 8 0 % I
% Lys: 0 8 8 8 0 0 8 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 24 0 8 8 0 0 31 24 0 8 16 0 16 % L
% Met: 0 0 24 0 0 8 8 0 8 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 8 0 0 16 0 0 0 0 0 0 % N
% Pro: 16 0 0 0 8 0 0 8 0 0 0 8 16 0 0 % P
% Gln: 8 0 0 0 0 8 8 0 0 0 0 8 0 8 0 % Q
% Arg: 0 24 0 8 16 0 0 8 0 8 8 0 0 31 16 % R
% Ser: 0 8 0 0 0 0 8 0 0 0 0 8 16 8 0 % S
% Thr: 0 8 0 16 8 16 0 0 0 0 8 0 0 8 8 % T
% Val: 8 16 8 8 8 8 8 16 0 0 8 8 0 8 24 % V
% Trp: 0 0 8 0 0 0 8 0 0 8 8 16 0 0 8 % W
% Tyr: 8 0 0 0 8 0 0 24 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _