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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPAST All Species: 41.52
Human Site: S595 Identified Species: 70.26
UniProt: Q9UBP0 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBP0 NP_055761.2 616 67197 S595 S L K K I K R S V S P Q T L E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850973 624 68082 S603 S L K K I K R S V S P Q T L E
Cat Felis silvestris
Mouse Mus musculus Q9QYY8 614 66438 S593 S L K K I K R S V S P Q T L E
Rat Rattus norvegicus B2RYN7 581 63003 S560 S L K K I K R S V S P Q T L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509194 572 63669 S551 S L K K I K R S V S P Q T L E
Chicken Gallus gallus Q5ZK92 613 66247 S592 S L K K I K R S L S P Q T L E
Frog Xenopus laevis Q6AZT2 600 65835 S579 S L K K I K C S V S H S T L E
Zebra Danio Brachydanio rerio Q6NW58 570 63067 S548 S L K R I K R S V S P Q T L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8I0P1 758 82731 S737 S L K R I R R S V A P Q S L N
Honey Bee Apis mellifera XP_393080 682 76301 S661 S L K R I R R S V S P A S L A
Nematode Worm Caenorhab. elegans Q8MNV0 512 56883 R492 D T A L R T I R P S T S Q K I
Sea Urchin Strong. purpuratus O61577 516 57575 K496 L A L Q K V S K S V G K E D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 P503 E A I R K V Q P S V S S S D I
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 S876 S L V Y I K P S V S Q D G L V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 94.7 N.A. 92.5 88.9 N.A. 81.1 83.9 71 62.8 N.A. 42.8 46.9 33.7 30.3
Protein Similarity: 100 N.A. N.A. 95.8 N.A. 93.9 90 N.A. 84.4 88.4 80.8 73.3 N.A. 55.2 62 49.3 46.7
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 93.3 80 86.6 N.A. 66.6 66.6 6.6 0
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 100 80 100 N.A. 93.3 86.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 31 30.1 N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 8 0 0 0 0 0 0 8 0 8 0 0 8 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 0 0 8 0 15 8 % D
% Glu: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 50 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 8 0 79 0 8 0 0 0 0 0 0 0 15 % I
% Lys: 0 0 72 50 15 65 0 8 0 0 0 8 0 8 0 % K
% Leu: 8 79 8 8 0 0 0 0 8 0 0 0 0 79 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 8 8 8 0 65 0 0 0 0 % P
% Gln: 0 0 0 8 0 0 8 0 0 0 8 58 8 0 0 % Q
% Arg: 0 0 0 29 8 15 65 8 0 0 0 0 0 0 0 % R
% Ser: 79 0 0 0 0 0 8 79 15 79 8 22 22 0 0 % S
% Thr: 0 8 0 0 0 8 0 0 0 0 8 0 58 0 0 % T
% Val: 0 0 8 0 0 15 0 0 72 15 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _