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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPAST All Species: 16.36
Human Site: T306 Identified Species: 27.69
UniProt: Q9UBP0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBP0 NP_055761.2 616 67197 T306 N K P S T P T T A T R K K K D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850973 624 68082 T314 N K P S T P T T A A R K K K D
Cat Felis silvestris
Mouse Mus musculus Q9QYY8 614 66438 T304 N K P S T P T T A V R K K K D
Rat Rattus norvegicus B2RYN7 581 63003 T271 N K P S T P T T A V R K K K D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509194 572 63669 P262 N K P S T P T P A A R K K K D
Chicken Gallus gallus Q5ZK92 613 66247 P303 N K P S T P T P A A R K K K D
Frog Xenopus laevis Q6AZT2 600 65835 T290 T N K P A T P T T A V R K K D
Zebra Danio Brachydanio rerio Q6NW58 570 63067 A259 K A S T T A T A S P Q R K R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8I0P1 758 82731 S447 P I N N N G P S G S G A S T P
Honey Bee Apis mellifera XP_393080 682 76301 N372 T P T A S N S N R G T P T R K
Nematode Worm Caenorhab. elegans Q8MNV0 512 56883 V236 E V L D N T G V R M D D V A G
Sea Urchin Strong. purpuratus O61577 516 57575 T240 W A D I A G L T E A K R L L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 A247 D V A G L S E A K R L L E E A
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 M521 S K N Q T T S M S K T N R K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 94.7 N.A. 92.5 88.9 N.A. 81.1 83.9 71 62.8 N.A. 42.8 46.9 33.7 30.3
Protein Similarity: 100 N.A. N.A. 95.8 N.A. 93.9 90 N.A. 84.4 88.4 80.8 73.3 N.A. 55.2 62 49.3 46.7
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 93.3 93.3 N.A. 86.6 86.6 26.6 26.6 N.A. 0 0 0 6.6
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 93.3 93.3 N.A. 86.6 86.6 33.3 60 N.A. 20 26.6 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. 31 30.1 N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 8 8 15 8 0 15 43 36 0 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 8 0 0 0 0 0 0 8 8 0 0 58 % D
% Glu: 8 0 0 0 0 0 8 0 8 0 0 0 8 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 15 8 0 8 8 8 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 8 50 8 0 0 0 0 0 8 8 8 43 58 58 8 % K
% Leu: 0 0 8 0 8 0 8 0 0 0 8 8 8 8 0 % L
% Met: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % M
% Asn: 43 8 15 8 15 8 0 8 0 0 0 8 0 0 0 % N
% Pro: 8 8 43 8 0 43 15 15 0 8 0 8 0 0 8 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 15 8 43 22 8 15 0 % R
% Ser: 8 0 8 43 8 8 15 8 15 8 0 0 8 0 0 % S
% Thr: 15 0 8 8 58 22 50 43 8 8 15 0 8 8 0 % T
% Val: 0 15 0 0 0 0 0 8 0 15 8 0 8 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _