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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METTL1 All Species: 43.03
Human Site: Y115 Identified Species: 63.11
UniProt: Q9UBP6 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBP6 NP_005362.3 276 31471 Y115 I R V K V S D Y V Q D R I R A
Chimpanzee Pan troglodytes XP_001167352 301 34100 Y140 I R V K V S D Y V Q D R I R A
Rhesus Macaque Macaca mulatta XP_001116496 301 34160 Y140 I R V K V S D Y V Q D R I R A
Dog Lupus familis XP_849422 247 28132 N105 N I A C L R S N A M K H L P N
Cat Felis silvestris
Mouse Mus musculus Q9Z120 268 30585 Y109 I R V K V S D Y V Q D R I R A
Rat Rattus norvegicus XP_001054797 267 30550 Y108 I R V K V S D Y V Q D R I R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516298 226 25512 Q92 A A S E G G Y Q N I A C L R S
Chicken Gallus gallus
Frog Xenopus laevis Q6NU94 273 31824 Y117 I R V K V S D Y V Q D R I K S
Zebra Danio Brachydanio rerio Q5XJ57 241 27917 P105 R S L R V A E P G R Y Q N I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77263 256 29406 Y110 I R V K V S D Y V V D R I A A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23126 256 30022 Y105 I R V K V S D Y V N E K I Q A
Sea Urchin Strong. purpuratus XP_790960 406 47124 Y253 I R I K V S D Y V Q Q R I E A
Poplar Tree Populus trichocarpa
Maize Zea mays B6SHG7 255 29101 Y106 L R D K V T E Y V K E R I L A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GXB7 251 28800 R106 V T E Y V K E R I L A L R R T
Baker's Yeast Sacchar. cerevisiae Q12009 286 33373 Y134 I R V Q V T N Y V E D R I I A
Red Bread Mold Neurospora crassa Q7RZC1 293 33715 F136 I R V S V T Q F V E D R I K A
Conservation
Percent
Protein Identity: 100 90.6 90.6 81.5 N.A. 88 88.4 N.A. 64.8 N.A. 69.5 67.7 N.A. 47.4 N.A. 50.7 42.3
Protein Similarity: 100 91.3 91 83.6 N.A. 92.3 90.9 N.A. 72 N.A. 80 76.4 N.A. 59.7 N.A. 64.8 51.2
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. 6.6 N.A. 86.6 13.3 N.A. 86.6 N.A. 73.3 80
P-Site Similarity: 100 100 100 13.3 N.A. 100 100 N.A. 26.6 N.A. 100 53.3 N.A. 86.6 N.A. 93.3 86.6
Percent
Protein Identity: N.A. 52.5 N.A. 50 46.8 48.8
Protein Similarity: N.A. 68.4 N.A. 68.4 61.5 66.2
P-Site Identity: N.A. 53.3 N.A. 13.3 66.6 60
P-Site Similarity: N.A. 86.6 N.A. 33.3 93.3 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 0 0 7 0 0 7 0 13 0 0 7 75 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 0 0 7 0 0 0 57 0 0 0 57 0 0 0 0 % D
% Glu: 0 0 7 7 0 0 19 0 0 13 13 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 7 0 0 7 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 69 7 7 0 0 0 0 0 7 7 0 0 75 13 0 % I
% Lys: 0 0 0 63 0 7 0 0 0 7 7 7 0 13 0 % K
% Leu: 7 0 7 0 7 0 0 0 0 7 0 7 13 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 7 7 7 7 0 0 7 0 7 % N
% Pro: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % P
% Gln: 0 0 0 7 0 0 7 7 0 44 7 7 0 7 0 % Q
% Arg: 7 75 0 7 0 7 0 7 0 7 0 69 7 44 0 % R
% Ser: 0 7 7 7 0 57 7 0 0 0 0 0 0 0 13 % S
% Thr: 0 7 0 0 0 19 0 0 0 0 0 0 0 0 7 % T
% Val: 7 0 63 0 88 0 0 0 75 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 7 69 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _