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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METTL1 All Species: 20.61
Human Site: Y21 Identified Species: 30.22
UniProt: Q9UBP6 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBP6 NP_005362.3 276 31471 Y21 P P P Q K R Y Y R Q R A H S N
Chimpanzee Pan troglodytes XP_001167352 301 34100 Y46 P P P Q K R Y Y R Q R A H S N
Rhesus Macaque Macaca mulatta XP_001116496 301 34160 Y46 P P P Q K R Y Y R Q R A H S N
Dog Lupus familis XP_849422 247 28132 P21 L Y P E F F A P L T Q N K T H
Cat Felis silvestris
Mouse Mus musculus Q9Z120 268 30585 A25 R A H S N P M A D H T L R Y P
Rat Rattus norvegicus XP_001054797 267 30550 A24 R A H S N P M A D H T L R Y P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516298 226 25512 R8 M S S S S P V R P E D M D W S
Chicken Gallus gallus
Frog Xenopus laevis Q6NU94 273 31824 Y23 T L P Q K R Y Y R Q R A H S N
Zebra Danio Brachydanio rerio Q5XJ57 241 27917 A21 R A H S N P M A D H T F Q Y P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77263 256 29406 P22 Q E P D V L N P T S A V T G L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23126 256 30022 V21 H K P T C E T V P G L P Q K K
Sea Urchin Strong. purpuratus XP_790960 406 47124 N87 K K V R E A I N A K S S L A F
Poplar Tree Populus trichocarpa
Maize Zea mays B6SHG7 255 29101 A21 P R K R F Y R A R A H S N P L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GXB7 251 28800 Y22 G L P R K R F Y R A R A H S N
Baker's Yeast Sacchar. cerevisiae Q12009 286 33373 L28 K E E N R K E L K H V K I N E
Red Bread Mold Neurospora crassa Q7RZC1 293 33715 Y32 E L P R K K F Y R Q R A H A N
Conservation
Percent
Protein Identity: 100 90.6 90.6 81.5 N.A. 88 88.4 N.A. 64.8 N.A. 69.5 67.7 N.A. 47.4 N.A. 50.7 42.3
Protein Similarity: 100 91.3 91 83.6 N.A. 92.3 90.9 N.A. 72 N.A. 80 76.4 N.A. 59.7 N.A. 64.8 51.2
P-Site Identity: 100 100 100 6.6 N.A. 0 0 N.A. 0 N.A. 86.6 0 N.A. 6.6 N.A. 6.6 0
P-Site Similarity: 100 100 100 33.3 N.A. 0 0 N.A. 13.3 N.A. 86.6 0 N.A. 6.6 N.A. 6.6 33.3
Percent
Protein Identity: N.A. 52.5 N.A. 50 46.8 48.8
Protein Similarity: N.A. 68.4 N.A. 68.4 61.5 66.2
P-Site Identity: N.A. 13.3 N.A. 66.6 0 60
P-Site Similarity: N.A. 33.3 N.A. 80 26.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 0 7 7 25 7 13 7 38 0 13 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 0 0 19 0 7 0 7 0 0 % D
% Glu: 7 13 7 7 7 7 7 0 0 7 0 0 0 0 7 % E
% Phe: 0 0 0 0 13 7 13 0 0 0 0 7 0 0 7 % F
% Gly: 7 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % G
% His: 7 0 19 0 0 0 0 0 0 25 7 0 38 0 7 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 0 0 7 0 0 % I
% Lys: 13 13 7 0 38 13 0 0 7 7 0 7 7 7 7 % K
% Leu: 7 19 0 0 0 7 0 7 7 0 7 13 7 0 13 % L
% Met: 7 0 0 0 0 0 19 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 7 19 0 7 7 0 0 0 7 7 7 38 % N
% Pro: 25 19 57 0 0 25 0 13 13 0 0 7 0 7 19 % P
% Gln: 7 0 0 25 0 0 0 0 0 32 7 0 13 0 0 % Q
% Arg: 19 7 0 25 7 32 7 7 44 0 38 0 13 0 0 % R
% Ser: 0 7 7 25 7 0 0 0 0 7 7 13 0 32 7 % S
% Thr: 7 0 0 7 0 0 7 0 7 7 19 0 7 7 0 % T
% Val: 0 0 7 0 7 0 7 7 0 0 7 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 7 0 0 0 7 25 38 0 0 0 0 0 19 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _