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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLK All Species: 13.94
Human Site: S566 Identified Species: 25.56
UniProt: Q9UBT6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBT6 NP_057302.1 870 98809 S566 L E M S H K K S F F D K K R S
Chimpanzee Pan troglodytes XP_001149102 871 98970 S566 L E M S H K K S F F D K K R S
Rhesus Macaque Macaca mulatta XP_001105220 870 98368 S566 L E M S H K K S F F D K K R S
Dog Lupus familis XP_536321 861 97742 S562 F L K S L E M S H K K S F F D
Cat Felis silvestris
Mouse Mus musculus Q9QUG2 852 95984 E553 L D K T D K T E L A K P L E M
Rat Rattus norvegicus NP_612525 851 95088 E553 A D R T D K T E L V K P L E T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512578 873 99083 S567 Q E M A P K E S F F N K K R A
Chicken Gallus gallus NP_989514 867 97411 F559 E A S S R G S F F D K K R A A
Frog Xenopus laevis NP_001086552 862 96259 R559 A L A T G P Q R Q S F F N Q K
Zebra Danio Brachydanio rerio XP_691219 888 99434 Q530 G A R F L K P Q S T E M K V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34409 503 57292 D207 K R H R F G G D C P C W L P R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002300273 323 35959 E27 G S K Y F E N E E K K E A L L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_175420 671 75234 K375 E M L S H D M K K E G L T A R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 83.7 N.A. 76.4 73.2 N.A. 66.3 56.9 55.8 48.5 N.A. N.A. N.A. 28.2 N.A.
Protein Similarity: 100 99.3 97.2 90.1 N.A. 85.6 83.2 N.A. 78.2 70.6 67.9 63.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 13.3 N.A. 13.3 6.6 N.A. 60 20 0 13.3 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 100 20 N.A. 26.6 26.6 N.A. 86.6 33.3 20 20 N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: 20.9 N.A. N.A. 31.6 N.A. N.A.
Protein Similarity: 29.2 N.A. N.A. 48 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 16 8 8 0 0 0 0 0 8 0 0 8 16 16 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % C
% Asp: 0 16 0 0 16 8 0 8 0 8 24 0 0 0 8 % D
% Glu: 16 31 0 0 0 16 8 24 8 8 8 8 0 16 0 % E
% Phe: 8 0 0 8 16 0 0 8 39 31 8 8 8 8 0 % F
% Gly: 16 0 0 0 8 16 8 0 0 0 8 0 0 0 0 % G
% His: 0 0 8 0 31 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 24 0 0 54 24 8 8 16 39 39 39 0 8 % K
% Leu: 31 16 8 0 16 0 0 0 16 0 0 8 24 8 8 % L
% Met: 0 8 31 0 0 0 16 0 0 0 0 8 0 0 8 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 8 0 8 0 0 % N
% Pro: 0 0 0 0 8 8 8 0 0 8 0 16 0 8 8 % P
% Gln: 8 0 0 0 0 0 8 8 8 0 0 0 0 8 0 % Q
% Arg: 0 8 16 8 8 0 0 8 0 0 0 0 8 31 16 % R
% Ser: 0 8 8 47 0 0 8 39 8 8 0 8 0 0 24 % S
% Thr: 0 0 0 24 0 0 16 0 0 8 0 0 8 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _