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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX1-2
All Species:
1.52
Human Site:
S60
Identified Species:
3.33
UniProt:
Q9UD57
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UD57
XP_002343058.1
332
34708
S60
V
E
A
G
K
D
A
S
S
R
D
P
V
R
Q
Chimpanzee
Pan troglodytes
XP_521630
398
41798
A126
F
T
R
A
A
L
P
A
V
R
P
A
P
R
E
Rhesus Macaque
Macaca mulatta
Q2VL87
297
30903
F55
V
S
P
S
L
L
P
F
S
V
E
A
L
M
A
Dog
Lupus familis
XP_544059
354
36219
A77
F
T
R
A
A
L
P
A
V
R
P
A
P
R
E
Cat
Felis silvestris
Mouse
Mus musculus
P42580
305
31994
L50
A
L
E
A
K
K
S
L
E
E
V
E
A
G
Q
Rat
Rattus norvegicus
P63156
327
35117
A69
S
T
S
R
P
G
A
A
S
G
P
G
L
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P19601
232
25205
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q98876
276
29946
S43
V
S
T
V
T
D
S
S
F
F
S
S
S
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
P15858
74
8968
Nematode Worm
Caenorhab. elegans
P53547
132
14911
Sea Urchin
Strong. purpuratus
NP_001009577
432
47583
D177
S
M
A
H
H
G
V
D
T
A
S
P
F
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.3
26.5
60.1
N.A.
69.8
26.5
N.A.
N.A.
38.8
N.A.
22.8
N.A.
N.A.
20.1
20.4
29.8
Protein Similarity:
100
71.1
34.9
65.8
N.A.
75.3
35.8
N.A.
N.A.
43
N.A.
35.8
N.A.
N.A.
21.3
23.7
40.5
P-Site Identity:
100
13.3
13.3
13.3
N.A.
13.3
13.3
N.A.
N.A.
0
N.A.
20
N.A.
N.A.
0
0
13.3
P-Site Similarity:
100
26.6
26.6
26.6
N.A.
20
33.3
N.A.
N.A.
0
N.A.
33.3
N.A.
N.A.
0
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
28
19
0
19
28
0
10
0
28
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
19
0
10
0
0
10
0
0
10
0
% D
% Glu:
0
10
10
0
0
0
0
0
10
10
10
10
0
0
19
% E
% Phe:
19
0
0
0
0
0
0
10
10
10
0
0
10
10
0
% F
% Gly:
0
0
0
10
0
19
0
0
0
10
0
10
0
10
0
% G
% His:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
19
10
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
10
28
0
10
0
0
0
0
19
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
0
10
0
28
0
0
0
28
19
19
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
19
% Q
% Arg:
0
0
19
10
0
0
0
0
0
28
0
0
0
28
0
% R
% Ser:
19
19
10
10
0
0
19
19
28
0
19
10
10
0
19
% S
% Thr:
0
28
10
0
10
0
0
0
10
0
0
0
0
0
10
% T
% Val:
28
0
0
10
0
0
10
0
19
10
10
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _