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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRODH2 All Species: 17.27
Human Site: Y383 Identified Species: 29.23
UniProt: Q9UF12 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UF12 NP_067055.1 536 58871 Y383 V K L V R G A Y L D K E R A V
Chimpanzee Pan troglodytes XP_524461 536 58825 Y383 V K L V R G A Y L D K E R A V
Rhesus Macaque Macaca mulatta XP_001112278 458 50173 W316 V A A L A V R W N S P G E G G
Dog Lupus familis XP_541686 567 62920 G376 T K R M W D L G I P L D G P V
Cat Felis silvestris
Mouse Mus musculus Q8VCZ9 456 50705 M314 Y L D K E R S M T Q L Q G K E
Rat Rattus norvegicus Q2V057 456 50984 V314 Y L D K E R S V T Q L H G K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6PAY6 466 52311 K323 A Y M D K E R K L S K Q K G Y
Zebra Danio Brachydanio rerio NP_001002391 465 52716 Y323 W E H T N D S Y N G C L E L M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q04499 681 77135 Y514 A K L V R G A Y M D Q E R D R
Honey Bee Apis mellifera XP_395275 528 60938 Y361 A K L V R G A Y I E Q E R A R
Nematode Worm Caenorhab. elegans O45228 616 69804 Y457 A K L V R G A Y M E Q E R A R
Sea Urchin Strong. purpuratus XP_782069 402 44953 G259 M A Q E S D T G R L E G V P D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92983 499 54937 L357 Y M S S E A S L A D S L G C K
Baker's Yeast Sacchar. cerevisiae P09368 476 53253 R334 Y I H S E K N R N Q I I F G D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 78.7 69.3 N.A. 69.7 69.2 N.A. N.A. N.A. 46.4 41 N.A. 28.3 28.5 26.9 26.4
Protein Similarity: 100 99.6 81.1 73.9 N.A. 75.5 75 N.A. N.A. N.A. 60 55.5 N.A. 45.6 46.8 43 43.4
P-Site Identity: 100 100 6.6 13.3 N.A. 0 0 N.A. N.A. N.A. 13.3 6.6 N.A. 66.6 66.6 66.6 0
P-Site Similarity: 100 100 20 33.3 N.A. 13.3 6.6 N.A. N.A. N.A. 40 26.6 N.A. 80 86.6 86.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 25.9 21.8 N.A.
Protein Similarity: N.A. N.A. N.A. 45.1 38.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 29 15 8 0 8 8 36 0 8 0 0 0 0 29 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % C
% Asp: 0 0 15 8 0 22 0 0 0 29 0 8 0 8 15 % D
% Glu: 0 8 0 8 29 8 0 0 0 15 8 36 15 0 15 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 36 0 15 0 8 0 15 29 22 8 % G
% His: 0 0 15 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 15 0 8 8 0 0 0 % I
% Lys: 0 43 0 15 8 8 0 8 0 0 22 0 8 15 8 % K
% Leu: 0 15 36 8 0 0 8 8 22 8 22 15 0 8 0 % L
% Met: 8 8 8 8 0 0 0 8 15 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 8 0 8 0 22 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 8 0 0 15 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 22 22 15 0 0 0 % Q
% Arg: 0 0 8 0 36 15 15 8 8 0 0 0 36 0 22 % R
% Ser: 0 0 8 15 8 0 29 0 0 15 8 0 0 0 0 % S
% Thr: 8 0 0 8 0 0 8 0 15 0 0 0 0 0 0 % T
% Val: 22 0 0 36 0 8 0 8 0 0 0 0 8 0 22 % V
% Trp: 8 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 29 8 0 0 0 0 0 43 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _