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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PISD All Species: 40.61
Human Site: S285 Identified Species: 74.44
UniProt: Q9UG56 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UG56 NP_055153.1 408 46573 S285 H F P G S L M S V N P G M A R
Chimpanzee Pan troglodytes XP_515087 419 47798 S296 H F P G S L M S V N P G M A R
Rhesus Macaque Macaca mulatta XP_001111773 409 46891 S286 H F P G S L M S V N P G M A R
Dog Lupus familis XP_534739 409 46776 S286 H F P G S L M S V N P G M A R
Cat Felis silvestris
Mouse Mus musculus Q8BSF4 406 45908 S283 H F P G S L M S V N P G M A R
Rat Rattus norvegicus XP_002725046 409 45994 S286 H F P G S L M S V N P G M A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515601 373 42661 R257 S V N P G V A R W I K E L F C
Chicken Gallus gallus XP_415253 409 46521 S286 H F P G S L M S V N P G V A R
Frog Xenopus laevis NP_001087912 411 47318 S288 H F P G S L M S V N P G V A K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651208 447 50470 S312 H F S G E L L S V S P K V A G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10949 377 42469 S257 H V P G L L L S V R P T L L S
Sea Urchin Strong. purpuratus XP_001180823 382 43384 R260 S V N P G I A R W V R G L F N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39006 500 56576 S367 H F P G D L F S V A P Y F Q R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.3 96.8 91.1 N.A. 84.5 84.5 N.A. 73 79.2 64.2 N.A. N.A. 39.3 N.A. 34 48.7
Protein Similarity: 100 78.5 97.3 94.1 N.A. 89.2 89.2 N.A. 79.1 86.3 72.9 N.A. N.A. 52.7 N.A. 50.7 60.5
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 93.3 86.6 N.A. N.A. 53.3 N.A. 46.6 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 100 100 N.A. N.A. 73.3 N.A. 60 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 35 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 16 0 0 8 0 0 0 70 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 77 0 0 0 0 8 0 0 0 0 0 8 16 0 % F
% Gly: 0 0 0 85 16 0 0 0 0 0 0 70 0 0 8 % G
% His: 85 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 8 % K
% Leu: 0 0 0 0 8 85 16 0 0 0 0 0 24 8 0 % L
% Met: 0 0 0 0 0 0 62 0 0 0 0 0 47 0 0 % M
% Asn: 0 0 16 0 0 0 0 0 0 62 0 0 0 0 8 % N
% Pro: 0 0 77 16 0 0 0 0 0 0 85 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 16 0 8 8 0 0 0 62 % R
% Ser: 16 0 8 0 62 0 0 85 0 8 0 0 0 0 8 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % T
% Val: 0 24 0 0 0 8 0 0 85 8 0 0 24 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 16 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _