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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SERGEF All Species: 20.61
Human Site: T228 Identified Species: 45.33
UniProt: Q9UGK8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGK8 NP_036271.1 458 48981 T228 S D H S A S L T D A G E V Y V
Chimpanzee Pan troglodytes XP_521852 885 98391 T655 S D H S A S L T D A G E V Y V
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q80YD6 464 49207 T228 S D H S A S L T D T G E L Y V
Rat Rattus norvegicus XP_344892 450 47572 T228 S D H S A S L T D T G E L Y V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421009 341 35614 I131 P C L I P Q K I K Q S L K E K
Frog Xenopus laevis NP_001088703 394 41469 Q184 S H A R R F S Q Q K P I P A V
Zebra Danio Brachydanio rerio XP_694032 448 47864 T216 L R H A L A S T A S G C V Y Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608602 378 41496 Y168 L T Q D N K I Y V F G R L R I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781445 280 30061 P69 I N K L V R V P D L R P L K Q
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001141147 443 47140 T186 A E H T A A V T E D G D L Y G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P31386 333 36463 V123 Y E F T Q Q H V P L N S N D E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.1 N.A. N.A. N.A. 72.1 73.5 N.A. N.A. 46.9 43.8 46 N.A. 26.2 N.A. N.A. 26.4
Protein Similarity: 100 50.7 N.A. N.A. N.A. 81 81.2 N.A. N.A. 56.9 59.8 61.5 N.A. 40.6 N.A. N.A. 37.5
P-Site Identity: 100 100 N.A. N.A. N.A. 86.6 86.6 N.A. N.A. 0 13.3 33.3 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 100 N.A. N.A. N.A. 93.3 93.3 N.A. N.A. 0 13.3 53.3 N.A. 26.6 N.A. N.A. 26.6
Percent
Protein Identity: N.A. 28.3 N.A. N.A. 24.4 N.A.
Protein Similarity: N.A. 44.3 N.A. N.A. 37.5 N.A.
P-Site Identity: N.A. 33.3 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 86.6 N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 46 19 0 0 10 19 0 0 0 10 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 0 37 0 10 0 0 0 0 46 10 0 10 0 10 0 % D
% Glu: 0 19 0 0 0 0 0 0 10 0 0 37 0 10 10 % E
% Phe: 0 0 10 0 0 10 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 64 0 0 0 10 % G
% His: 0 10 55 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 10 0 0 10 10 0 0 0 10 0 0 10 % I
% Lys: 0 0 10 0 0 10 10 0 10 10 0 0 10 10 10 % K
% Leu: 19 0 10 10 10 0 37 0 0 19 0 10 46 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 10 0 0 0 0 0 10 0 10 0 0 % N
% Pro: 10 0 0 0 10 0 0 10 10 0 10 10 10 0 0 % P
% Gln: 0 0 10 0 10 19 0 10 10 10 0 0 0 0 19 % Q
% Arg: 0 10 0 10 10 10 0 0 0 0 10 10 0 10 0 % R
% Ser: 46 0 0 37 0 37 19 0 0 10 10 10 0 0 0 % S
% Thr: 0 10 0 19 0 0 0 55 0 19 0 0 0 0 0 % T
% Val: 0 0 0 0 10 0 19 10 10 0 0 0 28 0 46 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 10 0 0 0 0 0 55 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _