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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KDM5B All Species: 18.18
Human Site: S1375 Identified Species: 40
UniProt: Q9UGL1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGL1 NP_006609.3 1544 175645 S1375 Q T L L A K P S P A Q Q T D R
Chimpanzee Pan troglodytes Q5XUN4 1535 173724 V1368 L P Q L T G P V L E L P E A I
Rhesus Macaque Macaca mulatta XP_001090508 1411 159177 F1242 W W E W D T K F L C P L C M R
Dog Lupus familis XP_537122 1727 195532 T1558 Q T L L A K P T P A Q Q T D R
Cat Felis silvestris
Mouse Mus musculus Q80Y84 1544 175537 S1375 Q T L L T K P S S V Q Q A D R
Rat Rattus norvegicus NP_001100647 1544 175257 S1375 Q T L L T K P S S A Q Q A D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508780 1538 174757 S1369 Q T L L T K P S P P K Q S D R
Chicken Gallus gallus Q5F3R2 1522 173443 S1350 Q I L F T K Q S P S L Q A E Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6IQX0 1503 171080 M1335 S P E L E E L M V E G L V L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VMJ7 1838 203974 R1551 R V V Q Y M Q R Q R Q Q H T N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23541 1477 170773 D1311 K S G E S S D D I C K I A L F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 46.5 46.3 84.7 N.A. 94.2 93.9 N.A. 89.9 82.7 N.A. 63.3 N.A. 35.2 N.A. 29.2 N.A.
Protein Similarity: 100 64.5 61.3 86.7 N.A. 96.6 96.5 N.A. 94.7 90.4 N.A. 76.4 N.A. 50.5 N.A. 49 N.A.
P-Site Identity: 100 13.3 6.6 93.3 N.A. 73.3 80 N.A. 73.3 40 N.A. 6.6 N.A. 13.3 N.A. 0 N.A.
P-Site Similarity: 100 13.3 6.6 100 N.A. 73.3 80 N.A. 86.6 60 N.A. 20 N.A. 26.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 19 0 0 0 0 28 0 0 37 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 19 0 0 10 0 0 % C
% Asp: 0 0 0 0 10 0 10 10 0 0 0 0 0 46 0 % D
% Glu: 0 0 19 10 10 10 0 0 0 19 0 0 10 10 0 % E
% Phe: 0 0 0 10 0 0 0 10 0 0 0 0 0 0 10 % F
% Gly: 0 0 10 0 0 10 0 0 0 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 10 0 0 0 0 0 0 10 0 0 10 0 0 10 % I
% Lys: 10 0 0 0 0 55 10 0 0 0 19 0 0 0 0 % K
% Leu: 10 0 55 64 0 0 10 0 19 0 19 19 0 19 0 % L
% Met: 0 0 0 0 0 10 0 10 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 19 0 0 0 0 55 0 37 10 10 10 0 0 0 % P
% Gln: 55 0 10 10 0 0 19 0 10 0 46 64 0 0 19 % Q
% Arg: 10 0 0 0 0 0 0 10 0 10 0 0 0 0 55 % R
% Ser: 10 10 0 0 10 10 0 46 19 10 0 0 10 0 0 % S
% Thr: 0 46 0 0 46 10 0 10 0 0 0 0 19 10 0 % T
% Val: 0 10 10 0 0 0 0 10 10 10 0 0 10 0 0 % V
% Trp: 10 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _