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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PARP2 All Species: 14.85
Human Site: S226 Identified Species: 27.22
UniProt: Q9UGN5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGN5 NP_001036083.1 583 66206 S226 K K E E S L K S P L K P E S Q
Chimpanzee Pan troglodytes XP_001137329 531 60196 S226 K K E E S L K S P L K P E S Q
Rhesus Macaque Macaca mulatta XP_001088314 583 66217 S226 K K E E S L K S P L K P E S Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O88554 559 63378 L220 R V Q E L L K L I C N V Q T M
Rat Rattus norvegicus P27008 1014 112642 S663 A V K P G T K S K L P K P V Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26446 1011 113502 S660 T V S A G T K S K L A K P I Q
Frog Xenopus laevis P31669 998 111108 S646 S V G A G T K S K L A K P V Q
Zebra Danio Brachydanio rerio XP_001923129 647 72923 P295 P S A T Q K K P C Q L N S K V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35875 994 113773 L647 S H F F T S K L E I S V Q N L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N4H4 945 107988 L588 I T P G S K T L L P K S V K E
Sea Urchin Strong. purpuratus XP_001199118 736 83866 P386 G D A K E S K P K V P S K L D
Poplar Tree Populus trichocarpa
Maize Zea mays O50017 653 72977 E301 S I T D Q I K E T K L E T R I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q11207 637 72157 S280 N D I P S S S S E V K P E Q S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 97.4 N.A. N.A. 84.2 27.1 N.A. N.A. 27.9 25.7 55.6 N.A. 26.6 N.A. 23.8 42.5
Protein Similarity: 100 91 98.4 N.A. N.A. 90.7 40.2 N.A. N.A. 40.9 41 70.9 N.A. 40.8 N.A. 38.7 56.2
P-Site Identity: 100 100 100 N.A. N.A. 20 26.6 N.A. N.A. 26.6 26.6 6.6 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 100 N.A. N.A. 46.6 33.3 N.A. N.A. 26.6 26.6 6.6 N.A. 33.3 N.A. 20 26.6
Percent
Protein Identity: N.A. 42.5 N.A. 41.6 N.A. N.A.
Protein Similarity: N.A. 56.8 N.A. 57.6 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 33.3 N.A. N.A.
P-Site Similarity: N.A. 20 N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 16 0 0 0 0 0 0 16 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % C
% Asp: 0 16 0 8 0 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 0 0 24 31 8 0 0 8 16 0 0 8 31 0 8 % E
% Phe: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 8 24 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 8 0 0 8 0 0 8 8 0 0 0 8 8 % I
% Lys: 24 24 8 8 0 16 85 0 31 8 39 24 8 16 0 % K
% Leu: 0 0 0 0 8 31 0 24 8 47 16 0 0 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % N
% Pro: 8 0 8 16 0 0 0 16 24 8 16 31 24 0 0 % P
% Gln: 0 0 8 0 16 0 0 0 0 8 0 0 16 8 47 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % R
% Ser: 24 8 8 0 39 24 8 54 0 0 8 16 8 24 8 % S
% Thr: 8 8 8 8 8 24 8 0 8 0 0 0 8 8 0 % T
% Val: 0 31 0 0 0 0 0 0 0 16 0 16 8 16 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _