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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLL All Species: 26.67
Human Site: S246 Identified Species: 53.33
UniProt: Q9UGP5 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGP5 NP_037406.1 575 63482 S246 W V C A Q P S S Q K A T N H N
Chimpanzee Pan troglodytes XP_507992 575 63394 S246 W V C A Q P S S Q K A T N H N
Rhesus Macaque Macaca mulatta XP_001110483 575 63575 S246 W V C A Q P S S Q K A T N H N
Dog Lupus familis XP_850651 576 63314 S247 W V C A Q P S S Q K A V N H N
Cat Felis silvestris
Mouse Mus musculus Q9QXE2 573 62924 S244 W V C A Q P S S Q K A T N Y N
Rat Rattus norvegicus Q5RKI3 573 62383 S244 W V C A Q P S S Q K A T N Y N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511409 1156 126349 S260 W V C S Q P S S Q K K T N H N
Chicken Gallus gallus XP_001232209 575 63775 N246 W V C A Q S S N S K K E N H N
Frog Xenopus laevis O57383 334 38275 D17 S P N E G I T D F L V E L A N
Zebra Danio Brachydanio rerio Q6DRD3 336 38547 V19 E G I T D F L V E L A N Y E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785226 410 45521 E93 F C R I M K Y E E S Q V P D R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172522 529 59569 K210 N I T E I F G K L I N I Y R A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97 85.4 N.A. 82.4 82.4 N.A. 33.8 66.7 22 21.5 N.A. N.A. N.A. N.A. 20
Protein Similarity: 100 99.6 98.4 91.3 N.A. 88.3 88.8 N.A. 40.2 78 36.7 36.1 N.A. N.A. N.A. N.A. 37.7
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 86.6 66.6 6.6 6.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 93.3 73.3 13.3 13.3 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 29.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 59 0 0 0 0 0 0 59 0 0 9 9 % A
% Cys: 0 9 67 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 0 0 9 0 0 0 0 0 9 0 % D
% Glu: 9 0 0 17 0 0 0 9 17 0 0 17 0 9 0 % E
% Phe: 9 0 0 0 0 17 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 9 0 9 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 50 0 % H
% Ile: 0 9 9 9 9 9 0 0 0 9 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 9 0 9 0 67 17 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 9 0 9 17 0 0 9 0 0 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 9 0 0 0 0 9 0 0 9 9 67 0 75 % N
% Pro: 0 9 0 0 0 59 0 0 0 0 0 0 9 0 0 % P
% Gln: 0 0 0 0 67 0 0 0 59 0 9 0 0 0 0 % Q
% Arg: 0 0 9 0 0 0 0 0 0 0 0 0 0 9 17 % R
% Ser: 9 0 0 9 0 9 67 59 9 9 0 0 0 0 0 % S
% Thr: 0 0 9 9 0 0 9 0 0 0 0 50 0 0 0 % T
% Val: 0 67 0 0 0 0 0 9 0 0 9 17 0 0 0 % V
% Trp: 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 0 0 17 17 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _