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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC2A6 All Species: 8.48
Human Site: S377 Identified Species: 14.36
UniProt: Q9UGQ3 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGQ3 NP_001138571.1 507 54539 S377 N S T A G L E S E S W G D L A
Chimpanzee Pan troglodytes XP_528524 507 54553 S377 N S T A G L E S E S W G D L A
Rhesus Macaque Macaca mulatta XP_001118379 480 51222 A352 S A A I M F A A N L T L G L Y
Dog Lupus familis XP_548395 507 54801 S377 N S T M G L E S I P L G G T E
Cat Felis silvestris
Mouse Mus musculus Q9JIF3 477 51505 N350 L T Q S L P S N S S H V G L V
Rat Rattus norvegicus Q9JJZ1 478 51440 N350 L T Q S G P S N S S H V G L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520019 470 50144 P343 E I H N G T V P H P G G A L G
Chicken Gallus gallus P46896 490 54068 W362 T L L D Q M P W M S Y L S I V
Frog Xenopus laevis NP_001087681 465 51027 S338 N S T N R T M S I S S S A E P
Zebra Danio Brachydanio rerio XP_689092 432 47490 A305 Y D A A L V G A V R L I S V A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610694 488 53070 I348 A M I V T L S I L G G F F Y C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787337 482 52038 F353 L A V S S A T F G L Y Y Q V T
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147831 502 54145 L375 S A G M T L S L L V V A I V F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FRL3 487 52883 L360 S V G M T I S L V I V A A A F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 90.3 87.9 N.A. 42.4 43.5 N.A. 67.4 23.8 56.6 49.9 N.A. 32.9 N.A. N.A. 33.3
Protein Similarity: 100 100 91.7 91.9 N.A. 59.9 59.1 N.A. 77.1 43.5 73.3 63.7 N.A. 52 N.A. N.A. 53.6
P-Site Identity: 100 100 6.6 53.3 N.A. 13.3 20 N.A. 20 6.6 33.3 13.3 N.A. 6.6 N.A. N.A. 0
P-Site Similarity: 100 100 26.6 53.3 N.A. 33.3 40 N.A. 20 26.6 33.3 33.3 N.A. 6.6 N.A. N.A. 26.6
Percent
Protein Identity: N.A. 32.5 N.A. 30.5 N.A. N.A.
Protein Similarity: N.A. 54.2 N.A. 51.8 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 26.6 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 22 15 22 0 8 8 15 0 0 0 15 22 8 22 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 8 0 8 0 0 0 0 0 0 0 0 15 0 0 % D
% Glu: 8 0 0 0 0 0 22 0 15 0 0 0 0 8 8 % E
% Phe: 0 0 0 0 0 8 0 8 0 0 0 8 8 0 15 % F
% Gly: 0 0 15 0 36 0 8 0 8 8 15 29 29 0 8 % G
% His: 0 0 8 0 0 0 0 0 8 0 15 0 0 0 0 % H
% Ile: 0 8 8 8 0 8 0 8 15 8 0 8 8 8 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 22 8 8 0 15 36 0 15 15 15 15 15 0 43 8 % L
% Met: 0 8 0 22 8 8 8 0 8 0 0 0 0 0 0 % M
% Asn: 29 0 0 15 0 0 0 15 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 15 8 8 0 15 0 0 0 0 8 % P
% Gln: 0 0 15 0 8 0 0 0 0 0 0 0 8 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 22 29 0 22 8 0 36 29 15 43 8 8 15 0 0 % S
% Thr: 8 15 29 0 22 15 8 0 0 0 8 0 0 8 8 % T
% Val: 0 8 8 8 0 8 8 0 15 8 15 15 0 22 15 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 15 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 15 8 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _