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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH3
All Species:
18.79
Human Site:
S1257
Identified Species:
41.33
UniProt:
Q9UHC1
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC1
NP_001035197.1
1453
163712
S1257
G
R
K
K
L
L
S
S
T
L
I
P
P
L
E
Chimpanzee
Pan troglodytes
XP_001158381
1451
163337
S1255
G
R
K
K
L
L
S
S
T
L
I
P
P
L
E
Rhesus Macaque
Macaca mulatta
XP_001096911
1456
163780
S1260
G
R
K
K
L
L
S
S
T
L
I
P
P
L
E
Dog
Lupus familis
XP_537511
1456
164697
S1259
G
R
K
K
L
L
S
S
T
V
S
P
P
L
K
Cat
Felis silvestris
Mouse
Mus musculus
NP_780546
1411
158698
T1228
I
I
P
P
L
A
I
T
V
S
E
E
Q
R
R
Rat
Rattus norvegicus
NP_001101513
1442
161869
S1245
G
R
K
K
L
L
S
S
T
I
I
P
P
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516394
973
102513
S798
L
E
I
P
R
R
K
S
G
G
L
R
D
S
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085796
1235
137921
L1060
R
S
S
Q
N
I
G
L
S
L
S
F
P
D
T
Zebra Danio
Brachydanio rerio
XP_696739
1164
130422
P989
C
S
S
R
V
T
P
P
L
E
I
N
V
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001185665
1628
178951
E1435
A
H
E
R
I
R
L
E
M
L
I
Q
A
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_195277
1155
129267
L980
S
A
D
Q
E
L
V
L
P
E
M
G
Y
Q
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
94.6
78.8
N.A.
70.4
71.5
N.A.
30.8
N.A.
37.2
37.2
N.A.
N.A.
N.A.
N.A.
24.1
Protein Similarity:
100
99.3
96.6
87.1
N.A.
79.5
80.3
N.A.
43.3
N.A.
53
54.9
N.A.
N.A.
N.A.
N.A.
43
P-Site Identity:
100
100
100
80
N.A.
6.6
86.6
N.A.
6.6
N.A.
13.3
13.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
100
93.3
N.A.
13.3
93.3
N.A.
13.3
N.A.
33.3
26.6
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
0
10
0
0
0
0
0
0
10
0
10
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
0
0
0
0
0
0
10
10
0
% D
% Glu:
0
10
10
0
10
0
0
10
0
19
10
10
0
0
37
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
46
0
0
0
0
0
10
0
10
10
0
10
0
0
10
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
10
10
0
10
10
10
0
0
10
55
0
0
0
0
% I
% Lys:
0
0
46
46
0
0
10
0
0
0
0
0
0
0
10
% K
% Leu:
10
0
0
0
55
55
10
19
10
46
10
0
0
55
10
% L
% Met:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
10
19
0
0
10
10
10
0
0
46
55
0
0
% P
% Gln:
0
0
0
19
0
0
0
0
0
0
0
10
10
10
0
% Q
% Arg:
10
46
0
19
10
19
0
0
0
0
0
10
0
10
19
% R
% Ser:
10
19
19
0
0
0
46
55
10
10
19
0
0
10
0
% S
% Thr:
0
0
0
0
0
10
0
10
46
0
0
0
0
10
10
% T
% Val:
0
0
0
0
10
0
10
0
10
10
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _