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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH3
All Species:
7.88
Human Site:
S746
Identified Species:
17.33
UniProt:
Q9UHC1
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC1
NP_001035197.1
1453
163712
S746
P
I
V
R
K
K
L
S
L
S
S
Q
L
G
S
Chimpanzee
Pan troglodytes
XP_001158381
1451
163337
S746
V
R
K
K
L
S
L
S
S
Q
L
G
S
L
E
Rhesus Macaque
Macaca mulatta
XP_001096911
1456
163780
S749
P
I
V
R
K
K
L
S
L
S
S
Q
L
G
S
Dog
Lupus familis
XP_537511
1456
164697
L750
I
T
H
K
K
L
S
L
G
S
Q
L
G
S
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_780546
1411
158698
F739
K
I
D
K
R
G
S
F
K
Q
V
V
R
R
K
Rat
Rattus norvegicus
NP_001101513
1442
161869
V738
K
V
G
S
F
K
H
V
V
R
R
K
L
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516394
973
102513
V309
E
R
H
G
V
Y
V
V
N
V
R
C
H
V
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085796
1235
137921
S571
N
S
S
T
S
P
N
S
E
G
S
L
P
S
Y
Zebra Danio
Brachydanio rerio
XP_696739
1164
130422
K500
T
P
N
K
T
S
P
K
K
R
R
M
P
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001185665
1628
178951
S789
K
H
N
V
S
T
V
S
V
D
E
K
E
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_195277
1155
129267
F491
S
D
V
L
N
F
Q
F
Q
G
L
K
D
E
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
94.6
78.8
N.A.
70.4
71.5
N.A.
30.8
N.A.
37.2
37.2
N.A.
N.A.
N.A.
N.A.
24.1
Protein Similarity:
100
99.3
96.6
87.1
N.A.
79.5
80.3
N.A.
43.3
N.A.
53
54.9
N.A.
N.A.
N.A.
N.A.
43
P-Site Identity:
100
13.3
100
13.3
N.A.
6.6
13.3
N.A.
0
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
20
100
20
N.A.
20
33.3
N.A.
6.6
N.A.
13.3
13.3
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
0
10
10
0
0
0
0
0
0
10
0
0
10
0
0
% D
% Glu:
10
0
0
0
0
0
0
0
10
0
10
0
10
10
10
% E
% Phe:
0
0
0
0
10
10
0
19
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
0
10
0
0
10
19
0
10
10
28
10
% G
% His:
0
10
19
0
0
0
10
0
0
0
0
0
10
0
0
% H
% Ile:
10
28
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
28
0
10
37
28
28
0
10
19
0
0
28
0
0
10
% K
% Leu:
0
0
0
10
10
10
28
10
19
0
19
19
28
19
28
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
10
0
19
0
10
0
10
0
10
0
0
0
0
0
19
% N
% Pro:
19
10
0
0
0
10
10
0
0
0
0
0
19
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
10
19
10
19
0
0
0
% Q
% Arg:
0
19
0
19
10
0
0
0
0
19
28
0
10
10
0
% R
% Ser:
10
10
10
10
19
19
19
46
10
28
28
0
10
28
19
% S
% Thr:
10
10
0
10
10
10
0
0
0
0
0
0
0
0
0
% T
% Val:
10
10
28
10
10
0
19
19
19
10
10
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _