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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH3 All Species: 5.45
Human Site: S749 Identified Species: 12
UniProt: Q9UHC1 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC1 NP_001035197.1 1453 163712 S749 R K K L S L S S Q L G S L E K
Chimpanzee Pan troglodytes XP_001158381 1451 163337 L749 K L S L S S Q L G S L E K F K
Rhesus Macaque Macaca mulatta XP_001096911 1456 163780 S752 R K K L S L S S Q L G S L E K
Dog Lupus familis XP_537511 1456 164697 Q753 K K L S L G S Q L G S L E K F
Cat Felis silvestris
Mouse Mus musculus NP_780546 1411 158698 V742 K R G S F K Q V V R R K L S L
Rat Rattus norvegicus NP_001101513 1442 161869 R741 S F K H V V R R K L S L R S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516394 973 102513 R312 G V Y V V N V R C H V G E Y D
Chicken Gallus gallus
Frog Xenopus laevis NP_001085796 1235 137921 S574 T S P N S E G S L P S Y I T T
Zebra Danio Brachydanio rerio XP_696739 1164 130422 R503 K T S P K K R R M P L N D T E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001185665 1628 178951 E792 V S T V S V D E K E G N P A E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195277 1155 129267 L494 L N F Q F Q G L K D E L D V S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 94.6 78.8 N.A. 70.4 71.5 N.A. 30.8 N.A. 37.2 37.2 N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 99.3 96.6 87.1 N.A. 79.5 80.3 N.A. 43.3 N.A. 53 54.9 N.A. N.A. N.A. N.A. 43
P-Site Identity: 100 20 100 13.3 N.A. 6.6 13.3 N.A. 0 N.A. 13.3 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 26.6 100 26.6 N.A. 20 33.3 N.A. 6.6 N.A. 20 20 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. 23.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 0 10 0 0 19 0 10 % D
% Glu: 0 0 0 0 0 10 0 10 0 10 10 10 19 19 19 % E
% Phe: 0 10 10 0 19 0 0 0 0 0 0 0 0 10 10 % F
% Gly: 10 0 10 0 0 10 19 0 10 10 28 10 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 37 28 28 0 10 19 0 0 28 0 0 10 10 10 28 % K
% Leu: 10 10 10 28 10 19 0 19 19 28 19 28 28 0 10 % L
% Met: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 10 0 0 0 0 0 19 0 0 0 % N
% Pro: 0 0 10 10 0 0 0 0 0 19 0 0 10 0 0 % P
% Gln: 0 0 0 10 0 10 19 10 19 0 0 0 0 0 10 % Q
% Arg: 19 10 0 0 0 0 19 28 0 10 10 0 10 0 0 % R
% Ser: 10 19 19 19 46 10 28 28 0 10 28 19 0 19 10 % S
% Thr: 10 10 10 0 0 0 0 0 0 0 0 0 0 19 10 % T
% Val: 10 10 0 19 19 19 10 10 10 0 10 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _