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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLH3
All Species:
13.94
Human Site:
S833
Identified Species:
30.67
UniProt:
Q9UHC1
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC1
NP_001035197.1
1453
163712
S833
D
S
E
K
F
P
F
S
K
D
E
D
C
L
E
Chimpanzee
Pan troglodytes
XP_001158381
1451
163337
S831
D
S
E
K
F
P
F
S
K
D
E
D
C
L
E
Rhesus Macaque
Macaca mulatta
XP_001096911
1456
163780
S836
D
S
E
K
L
P
F
S
K
D
E
D
C
L
E
Dog
Lupus familis
XP_537511
1456
164697
S837
Y
P
K
K
F
P
F
S
N
E
E
D
C
L
E
Cat
Felis silvestris
Mouse
Mus musculus
NP_780546
1411
158698
I823
T
C
Q
P
L
S
P
I
L
Y
P
E
K
I
L
Rat
Rattus norvegicus
NP_001101513
1442
161869
P822
P
L
R
P
I
L
Y
P
E
T
L
S
K
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516394
973
102513
R393
G
G
G
R
E
S
F
R
K
A
C
D
D
L
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085796
1235
137921
S655
A
T
A
T
S
D
T
S
V
Y
V
K
Q
S
D
Zebra Danio
Brachydanio rerio
XP_696739
1164
130422
H584
T
S
C
L
D
D
L
H
H
P
V
L
R
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001185665
1628
178951
T1000
D
Q
T
L
D
D
G
T
S
C
P
S
M
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_195277
1155
129267
Q575
C
S
L
G
S
S
W
Q
D
T
D
W
F
T
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
94.6
78.8
N.A.
70.4
71.5
N.A.
30.8
N.A.
37.2
37.2
N.A.
N.A.
N.A.
N.A.
24.1
Protein Similarity:
100
99.3
96.6
87.1
N.A.
79.5
80.3
N.A.
43.3
N.A.
53
54.9
N.A.
N.A.
N.A.
N.A.
43
P-Site Identity:
100
100
93.3
66.6
N.A.
0
0
N.A.
26.6
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
80
N.A.
20
20
N.A.
33.3
N.A.
20
6.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% A
% Cys:
10
10
10
0
0
0
0
0
0
10
10
0
37
0
0
% C
% Asp:
37
0
0
0
19
28
0
0
10
28
10
46
10
0
19
% D
% Glu:
0
0
28
0
10
0
0
0
10
10
37
10
0
19
37
% E
% Phe:
0
0
0
0
28
0
46
0
0
0
0
0
10
0
0
% F
% Gly:
10
10
10
10
0
0
10
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
0
0
0
0
0
10
0
% I
% Lys:
0
0
10
37
0
0
0
0
37
0
0
10
19
0
0
% K
% Leu:
0
10
10
19
19
10
10
0
10
0
10
10
0
46
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% N
% Pro:
10
10
0
19
0
37
10
10
0
10
19
0
0
0
10
% P
% Gln:
0
10
10
0
0
0
0
10
0
0
0
0
10
0
0
% Q
% Arg:
0
0
10
10
0
0
0
10
0
0
0
0
10
0
0
% R
% Ser:
0
46
0
0
19
28
0
46
10
0
0
19
0
10
10
% S
% Thr:
19
10
10
10
0
0
10
10
0
19
0
0
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
19
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% W
% Tyr:
10
0
0
0
0
0
10
0
0
19
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _