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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH3 All Species: 9.09
Human Site: S909 Identified Species: 20
UniProt: Q9UHC1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC1 NP_001035197.1 1453 163712 S909 S D S S R K D S K L C S V L T
Chimpanzee Pan troglodytes XP_001158381 1451 163337 S907 S D S S R K D S K L C S V L T
Rhesus Macaque Macaca mulatta XP_001096911 1456 163780 S912 S D S S R K E S K L C S V L T
Dog Lupus familis XP_537511 1456 164697 H913 S D S S R K D H D L C S G L T
Cat Felis silvestris
Mouse Mus musculus NP_780546 1411 158698 N899 T S E L P D S N P S W K D N S
Rat Rattus norvegicus NP_001101513 1442 161869 K898 P D S D P S W K D N S Q C A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516394 973 102513 L469 G R G P A C D L P R S V A A E
Chicken Gallus gallus
Frog Xenopus laevis NP_001085796 1235 137921 E731 P L T L P H Y E S L K Q N R S
Zebra Danio Brachydanio rerio XP_696739 1164 130422 D660 E K T L L D E D V L F G S S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001185665 1628 178951 I1076 T I D A D E S I S L L Y I P H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195277 1155 129267 W651 S T P S A T K W E S E Y Q K G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 94.6 78.8 N.A. 70.4 71.5 N.A. 30.8 N.A. 37.2 37.2 N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 99.3 96.6 87.1 N.A. 79.5 80.3 N.A. 43.3 N.A. 53 54.9 N.A. N.A. N.A. N.A. 43
P-Site Identity: 100 100 93.3 80 N.A. 0 13.3 N.A. 6.6 N.A. 6.6 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 80 N.A. 20 13.3 N.A. 6.6 N.A. 20 20 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 23.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 19 0 0 0 0 0 0 0 10 19 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 37 0 10 0 0 % C
% Asp: 0 46 10 10 10 19 37 10 19 0 0 0 10 0 0 % D
% Glu: 10 0 10 0 0 10 19 10 10 0 10 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 10 0 10 0 0 0 0 0 0 0 0 10 10 0 19 % G
% His: 0 0 0 0 0 10 0 10 0 0 0 0 0 0 10 % H
% Ile: 0 10 0 0 0 0 0 10 0 0 0 0 10 0 0 % I
% Lys: 0 10 0 0 0 37 10 10 28 0 10 10 0 10 0 % K
% Leu: 0 10 0 28 10 0 0 10 0 64 10 0 0 37 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 10 0 0 10 10 0 % N
% Pro: 19 0 10 10 28 0 0 0 19 0 0 0 0 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 19 10 0 0 % Q
% Arg: 0 10 0 0 37 0 0 0 0 10 0 0 0 10 10 % R
% Ser: 46 10 46 46 0 10 19 28 19 19 19 37 10 10 19 % S
% Thr: 19 10 19 0 0 10 0 0 0 0 0 0 0 0 37 % T
% Val: 0 0 0 0 0 0 0 0 10 0 0 10 28 0 0 % V
% Trp: 0 0 0 0 0 0 10 10 0 0 10 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 19 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _