KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1L1
All Species:
4.55
Human Site:
S1327
Identified Species:
12.5
UniProt:
Q9UHC9
Number Species:
8
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC9
NP_001095118.1
1359
148698
S1327
P
N
H
P
S
R
V
S
T
A
D
N
I
Y
V
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
L1247
L
I
F
L
P
V
L
L
S
Y
I
G
P
S
V
Rhesus Macaque
Macaca mulatta
NP_001071157
1332
145570
S1300
P
N
H
P
S
R
V
S
T
A
D
N
I
Y
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q6T3U4
1333
147113
N1302
Y
P
F
P
A
D
A
N
T
S
D
Y
V
N
Y
Rat
Rattus norvegicus
Q6T3U3
1331
146397
D1302
Y
P
S
P
A
D
A
D
A
N
V
N
Y
G
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624752
1358
152373
C1324
N
K
Y
K
S
Q
V
C
G
P
D
S
P
L
L
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
D1346
L
K
A
E
G
G
I
D
K
A
I
D
I
I
T
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
E1303
V
N
K
A
R
I
L
E
E
Q
E
Q
A
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
A1141
W
F
T
L
I
I
V
A
A
L
H
A
L
L
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39.3
93.8
N.A.
N.A.
75.9
76.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
25.8
39.8
Protein Similarity:
100
56.8
95.3
N.A.
N.A.
85
85.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
57.6
46.7
58.6
P-Site Identity:
100
6.6
100
N.A.
N.A.
20
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
13.3
6.6
P-Site Similarity:
100
20
100
N.A.
N.A.
46.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
12
23
0
23
12
23
34
0
12
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
23
0
23
0
0
45
12
0
0
0
% D
% Glu:
0
0
0
12
0
0
0
12
12
0
12
0
0
0
0
% E
% Phe:
0
12
23
0
0
0
0
0
0
0
0
0
0
0
23
% F
% Gly:
0
0
0
0
12
12
0
0
12
0
0
12
0
12
12
% G
% His:
0
0
23
0
0
0
0
0
0
0
12
0
0
0
0
% H
% Ile:
0
12
0
0
12
23
12
0
0
0
23
0
34
12
0
% I
% Lys:
0
23
12
12
0
0
0
0
12
0
0
0
0
0
0
% K
% Leu:
23
0
0
23
0
0
23
12
0
12
0
0
12
23
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
34
0
0
0
0
0
12
0
12
0
34
0
12
0
% N
% Pro:
23
23
0
45
12
0
0
0
0
12
0
0
23
0
0
% P
% Gln:
0
0
0
0
0
12
0
0
0
12
0
12
0
0
0
% Q
% Arg:
0
0
0
0
12
23
0
0
0
0
0
0
0
12
0
% R
% Ser:
0
0
12
0
34
0
0
23
12
12
0
12
0
12
0
% S
% Thr:
0
0
12
0
0
0
0
0
34
0
0
0
0
0
12
% T
% Val:
12
0
0
0
0
12
45
0
0
0
12
0
12
0
34
% V
% Trp:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
23
0
12
0
0
0
0
0
0
12
0
12
12
23
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _