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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1L1 All Species: 8.48
Human Site: S324 Identified Species: 23.33
UniProt: Q9UHC9 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC9 NP_001095118.1 1359 148698 S324 V D P K K G T S L S D K L S F
Chimpanzee Pan troglodytes XP_001155285 1277 141871 S322 A S D K G E A S C C D P V S A
Rhesus Macaque Macaca mulatta NP_001071157 1332 145570 S324 V D P K K G T S L S D K L S F
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q6T3U4 1333 147113 N324 A G S Q E A P N L P R K R R F
Rat Rattus norvegicus Q6T3U3 1331 146397 K324 E G P Q E A P K L P H K H K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624752 1358 152373 T313 F D D E E Q S T F I E R L G A
Nematode Worm Caenorhab. elegans Q19127 1383 155438 N325 G E E S P K R N R I K R T G A
Sea Urchin Strong. purpuratus XP_780036 1332 147422 G358 E I S E D E V G C K A S C G M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 C232 D A Q Y K C A C S D C Q E S C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.3 93.8 N.A. N.A. 75.9 76.5 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 36.7 25.8 39.8
Protein Similarity: 100 56.8 95.3 N.A. N.A. 85 85.2 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 57.6 46.7 58.6
P-Site Identity: 100 26.6 100 N.A. N.A. 20 20 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 13.3 0 0
P-Site Similarity: 100 33.3 100 N.A. N.A. 40 33.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 53.3 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 23 12 0 0 0 23 23 0 0 0 12 0 0 0 34 % A
% Cys: 0 0 0 0 0 12 0 12 23 12 12 0 12 0 12 % C
% Asp: 12 34 23 0 12 0 0 0 0 12 34 0 0 0 0 % D
% Glu: 23 12 12 23 34 23 0 0 0 0 12 0 12 0 0 % E
% Phe: 12 0 0 0 0 0 0 0 12 0 0 0 0 0 34 % F
% Gly: 12 23 0 0 12 23 0 12 0 0 0 0 0 34 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 12 0 12 0 0 % H
% Ile: 0 12 0 0 0 0 0 0 0 23 0 0 0 0 0 % I
% Lys: 0 0 0 34 34 12 0 12 0 12 12 45 0 12 0 % K
% Leu: 0 0 0 0 0 0 0 0 45 0 0 0 34 0 12 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % M
% Asn: 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 % N
% Pro: 0 0 34 0 12 0 23 0 0 23 0 12 0 0 0 % P
% Gln: 0 0 12 23 0 12 0 0 0 0 0 12 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 12 0 12 23 12 12 0 % R
% Ser: 0 12 23 12 0 0 12 34 12 23 0 12 0 45 0 % S
% Thr: 0 0 0 0 0 0 23 12 0 0 0 0 12 0 0 % T
% Val: 23 0 0 0 0 0 12 0 0 0 0 0 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _