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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1L1 All Species: 13.33
Human Site: S433 Identified Species: 36.67
UniProt: Q9UHC9 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC9 NP_001095118.1 1359 148698 S433 L L G P K N F S G I L D L D L
Chimpanzee Pan troglodytes XP_001155285 1277 141871 F431 P S G A D V P F G P P L D I Q
Rhesus Macaque Macaca mulatta NP_001071157 1332 145570 S433 L L G P K N F S G I L D L D L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q6T3U4 1333 147113 S433 L L G P K N F S G I L S L D L
Rat Rattus norvegicus Q6T3U3 1331 146397 S433 L L G S K N F S G I L S L D F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624752 1358 152373 P422 N G Q I T F G P V F N D T F L
Nematode Worm Caenorhab. elegans Q19127 1383 155438 I434 G P V F H K D I F E E L F D I
Sea Urchin Strong. purpuratus XP_780036 1332 147422 T467 Y P S E A T T T Y G G I L S I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 I341 S V E N P Y K I L I T T V F S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.3 93.8 N.A. N.A. 75.9 76.5 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 36.7 25.8 39.8
Protein Similarity: 100 56.8 95.3 N.A. N.A. 85 85.2 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 57.6 46.7 58.6
P-Site Identity: 100 13.3 100 N.A. N.A. 93.3 80 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 13.3 6.6 6.6
P-Site Similarity: 100 13.3 100 N.A. N.A. 93.3 80 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 13.3 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 12 12 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 12 0 12 0 0 0 0 34 12 56 0 % D
% Glu: 0 0 12 12 0 0 0 0 0 12 12 0 0 0 0 % E
% Phe: 0 0 0 12 0 12 45 12 12 12 0 0 12 23 12 % F
% Gly: 12 12 56 0 0 0 12 0 56 12 12 0 0 0 0 % G
% His: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 12 0 0 0 23 0 56 0 12 0 12 23 % I
% Lys: 0 0 0 0 45 12 12 0 0 0 0 0 0 0 0 % K
% Leu: 45 45 0 0 0 0 0 0 12 0 45 23 56 0 45 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 0 0 12 0 45 0 0 0 0 12 0 0 0 0 % N
% Pro: 12 23 0 34 12 0 12 12 0 12 12 0 0 0 0 % P
% Gln: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 12 12 12 12 0 0 0 45 0 0 0 23 0 12 12 % S
% Thr: 0 0 0 0 12 12 12 12 0 0 12 12 12 0 0 % T
% Val: 0 12 12 0 0 12 0 0 12 0 0 0 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 12 0 0 0 0 12 0 0 12 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _