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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1L1
All Species:
13.33
Human Site:
S458
Identified Species:
36.67
UniProt:
Q9UHC9
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC9
NP_001095118.1
1359
148698
S458
L
R
H
L
Q
V
W
S
P
E
A
Q
R
N
I
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
A449
Q
V
L
D
L
Q
I
A
I
E
N
I
T
A
S
Rhesus Macaque
Macaca mulatta
NP_001071157
1332
145570
S458
L
R
H
L
Q
V
W
S
P
E
A
Q
R
N
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q6T3U4
1333
147113
S458
L
R
H
L
Q
V
W
S
H
E
A
Q
R
N
I
Rat
Rattus norvegicus
Q6T3U3
1331
146397
S458
L
R
H
L
Q
V
W
S
P
E
A
E
R
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624752
1358
152373
Q441
K
L
Q
E
E
I
K
Q
I
T
T
P
N
N
Y
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
R456
S
T
Q
D
S
D
G
R
T
I
T
L
D
D
V
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
N489
D
L
Q
D
A
V
V
N
L
K
V
P
F
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
I356
I
F
V
F
S
F
I
I
F
Q
Y
A
T
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39.3
93.8
N.A.
N.A.
75.9
76.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
25.8
39.8
Protein Similarity:
100
56.8
95.3
N.A.
N.A.
85
85.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
57.6
46.7
58.6
P-Site Identity:
100
6.6
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
0
6.6
P-Site Similarity:
100
13.3
100
N.A.
N.A.
93.3
100
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
0
12
0
0
45
12
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
34
0
12
0
0
0
0
0
0
12
12
0
% D
% Glu:
0
0
0
12
12
0
0
0
0
56
0
12
0
0
12
% E
% Phe:
0
12
0
12
0
12
0
0
12
0
0
0
12
0
0
% F
% Gly:
0
0
0
0
0
0
12
0
0
0
0
0
0
12
0
% G
% His:
0
0
45
0
0
0
0
0
12
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
0
12
23
12
23
12
0
12
0
0
45
% I
% Lys:
12
0
0
0
0
0
12
0
0
12
0
0
0
0
0
% K
% Leu:
45
23
12
45
12
0
0
0
12
0
0
12
0
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
12
0
0
12
0
12
56
12
% N
% Pro:
0
0
0
0
0
0
0
0
34
0
0
23
0
0
0
% P
% Gln:
12
0
34
0
45
12
0
12
0
12
0
34
0
0
0
% Q
% Arg:
0
45
0
0
0
0
0
12
0
0
0
0
45
0
0
% R
% Ser:
12
0
0
0
23
0
0
45
0
0
0
0
0
0
12
% S
% Thr:
0
12
0
0
0
0
0
0
12
12
23
0
23
0
0
% T
% Val:
0
12
12
0
0
56
12
0
0
0
12
0
0
0
12
% V
% Trp:
0
0
0
0
0
0
45
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _