Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1L1 All Species: 6.06
Human Site: Y1333 Identified Species: 16.67
UniProt: Q9UHC9 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC9 NP_001095118.1 1359 148698 Y1333 V S T A D N I Y V N H S F E G
Chimpanzee Pan troglodytes XP_001155285 1277 141871 S1253 L L S Y I G P S V N K A K S C
Rhesus Macaque Macaca mulatta NP_001071157 1332 145570 Y1306 V S T A D N I Y V N H S F E G
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q6T3U4 1333 147113 N1308 A N T S D Y V N Y G F N P E F
Rat Rattus norvegicus Q6T3U3 1331 146397 G1308 A D A N V N Y G F A P E L A H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624752 1358 152373 L1330 V C G P D S P L L Q N D N N Q
Nematode Worm Caenorhab. elegans Q19127 1383 155438 I1352 I D K A I D I I T I D R S Y P
Sea Urchin Strong. purpuratus XP_780036 1332 147422 R1309 L E E Q E Q A R G G R R G A D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 L1147 V A A L H A L L F L P A L L S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.3 93.8 N.A. N.A. 75.9 76.5 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 36.7 25.8 39.8
Protein Similarity: 100 56.8 95.3 N.A. N.A. 85 85.2 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 57.6 46.7 58.6
P-Site Identity: 100 13.3 100 N.A. N.A. 20 6.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 13.3 13.3 0
P-Site Similarity: 100 33.3 100 N.A. N.A. 46.6 6.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 33.3 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 23 12 23 34 0 12 12 0 0 12 0 23 0 23 0 % A
% Cys: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 12 % C
% Asp: 0 23 0 0 45 12 0 0 0 0 12 12 0 0 12 % D
% Glu: 0 12 12 0 12 0 0 0 0 0 0 12 0 34 0 % E
% Phe: 0 0 0 0 0 0 0 0 23 0 12 0 23 0 12 % F
% Gly: 0 0 12 0 0 12 0 12 12 23 0 0 12 0 23 % G
% His: 0 0 0 0 12 0 0 0 0 0 23 0 0 0 12 % H
% Ile: 12 0 0 0 23 0 34 12 0 12 0 0 0 0 0 % I
% Lys: 0 0 12 0 0 0 0 0 0 0 12 0 12 0 0 % K
% Leu: 23 12 0 12 0 0 12 23 12 12 0 0 23 12 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 12 0 12 0 34 0 12 0 34 12 12 12 12 0 % N
% Pro: 0 0 0 12 0 0 23 0 0 0 23 0 12 0 12 % P
% Gln: 0 0 0 12 0 12 0 0 0 12 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 0 0 12 0 0 12 23 0 0 0 % R
% Ser: 0 23 12 12 0 12 0 12 0 0 0 23 12 12 12 % S
% Thr: 0 0 34 0 0 0 0 0 12 0 0 0 0 0 0 % T
% Val: 45 0 0 0 12 0 12 0 34 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 12 0 12 12 23 12 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _