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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1L1 All Species: 19.7
Human Site: Y524 Identified Species: 54.17
UniProt: Q9UHC9 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UHC9 NP_001095118.1 1359 148698 Y524 D W K D H F L Y C A N A P L T
Chimpanzee Pan troglodytes XP_001155285 1277 141871 Y515 D Y H T H F L Y C V R A P A S
Rhesus Macaque Macaca mulatta NP_001071157 1332 145570 Y524 D W R D H F L Y C A N A P L T
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q6T3U4 1333 147113 Y524 D W K D H F L Y C A N A P L T
Rat Rattus norvegicus Q6T3U3 1331 146397 Y524 D W K D H F L Y C A N A P L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624752 1358 152373 V507 N Y L D H F I V C S Q N A Y N
Nematode Worm Caenorhab. elegans Q19127 1383 155438 H522 T T D E W M N H M A A C I D Q
Sea Urchin Strong. purpuratus XP_780036 1332 147422 S555 D F H E H L L S C A G S P A T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 I422 W F D V E N F I T E E L Q S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.3 93.8 N.A. N.A. 75.9 76.5 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 36.7 25.8 39.8
Protein Similarity: 100 56.8 95.3 N.A. N.A. 85 85.2 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 57.6 46.7 58.6
P-Site Identity: 100 53.3 93.3 N.A. N.A. 100 100 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 26.6 6.6 46.6
P-Site Similarity: 100 66.6 100 N.A. N.A. 100 100 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 53.3 20 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 67 12 56 12 23 0 % A
% Cys: 0 0 0 0 0 0 0 0 78 0 0 12 0 0 0 % C
% Asp: 67 0 23 56 0 0 0 0 0 0 0 0 0 12 0 % D
% Glu: 0 0 0 23 12 0 0 0 0 12 12 0 0 0 0 % E
% Phe: 0 23 0 0 0 67 12 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % G
% His: 0 0 23 0 78 0 0 12 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 12 12 0 0 0 0 12 0 0 % I
% Lys: 0 0 34 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 12 0 0 12 67 0 0 0 0 12 0 45 0 % L
% Met: 0 0 0 0 0 12 0 0 12 0 0 0 0 0 0 % M
% Asn: 12 0 0 0 0 12 12 0 0 0 45 12 0 0 12 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 67 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 12 0 12 0 12 % Q
% Arg: 0 0 12 0 0 0 0 0 0 0 12 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 12 0 12 0 12 0 12 23 % S
% Thr: 12 12 0 12 0 0 0 0 12 0 0 0 0 0 56 % T
% Val: 0 0 0 12 0 0 0 12 0 12 0 0 0 0 0 % V
% Trp: 12 45 0 0 12 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 23 0 0 0 0 0 56 0 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _