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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP25
All Species:
29.09
Human Site:
S130
Identified Species:
71.11
UniProt:
Q9UHP3
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHP3
NP_037528.3
1087
125750
S130
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Chimpanzee
Pan troglodytes
XP_531393
1087
125791
S130
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Rhesus Macaque
Macaca mulatta
XP_001107973
1166
134796
S209
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Dog
Lupus familis
XP_535562
1085
125476
S130
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Cat
Felis silvestris
Mouse
Mus musculus
P57080
1055
121402
S130
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Rat
Rattus norvegicus
NP_001100584
1055
121573
S131
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514451
1105
126985
S181
T
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
Chicken
Gallus gallus
Q5ZID5
1047
118729
S131
S
P
E
H
K
N
R
S
K
R
K
R
C
E
V
Frog
Xenopus laevis
NP_001086746
1046
121273
R130
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
A
Zebra Danio
Brachydanio rerio
NP_001001886
1072
123104
R130
D
E
E
Q
A
I
S
R
V
L
E
A
S
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
92.2
97.5
N.A.
91.1
91.5
N.A.
81.5
46.8
79.3
74.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
92.8
98.8
N.A.
93.7
94.1
N.A.
86.7
64.1
86.8
84.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
40
33.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
20
70
0
0
0
0
0
20
70
0
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
20
70
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
20
100
70
0
0
0
0
0
0
20
70
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
20
70
0
0
0
0
0
0
20
70
% I
% Lys:
0
0
0
0
10
0
0
0
10
0
10
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
20
70
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
20
70
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
20
70
10
0
10
0
0
0
% R
% Ser:
10
0
0
0
0
0
20
80
0
0
0
0
20
70
0
% S
% Thr:
70
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
20
70
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _