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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
9.7
Human Site:
S130
Identified Species:
15.24
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
S130
G
G
P
P
P
K
A
S
P
S
T
A
G
E
T
Chimpanzee
Pan troglodytes
XP_515356
522
57373
S129
G
G
P
P
P
K
A
S
P
S
T
A
G
E
T
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
Q46
L
R
K
E
K
K
Q
Q
K
K
K
R
K
E
E
Dog
Lupus familis
XP_860642
524
57645
C130
G
G
P
P
P
R
A
C
P
S
T
A
G
E
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
C130
G
G
V
P
P
Q
A
C
P
S
T
A
G
E
T
Rat
Rattus norvegicus
Q63186
524
57791
C130
G
G
P
S
P
Q
A
C
P
S
T
A
G
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
P154
Q
G
A
A
P
A
K
P
R
L
T
P
T
E
A
Frog
Xenopus laevis
NP_001088928
569
62292
K175
S
A
G
P
G
Q
G
K
A
K
A
V
S
I
E
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
P146
Q
Q
S
T
S
S
K
P
K
A
S
P
N
E
L
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
S200
E
K
A
P
V
A
A
S
A
A
P
S
T
T
E
Honey Bee
Apis mellifera
XP_001119855
484
53730
E93
Y
E
K
S
S
I
S
E
T
S
N
E
G
K
S
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
S120
G
G
G
G
G
S
S
S
L
P
S
S
G
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
T196
S
A
A
L
S
A
G
T
S
S
A
S
T
N
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
13.3
86.6
N.A.
80
73.3
N.A.
N.A.
26.6
6.6
6.6
0
20
13.3
0
26.6
P-Site Similarity:
100
100
13.3
93.3
N.A.
86.6
80
N.A.
N.A.
26.6
13.3
20
0
33.3
33.3
0
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
20
7
0
20
40
0
14
14
14
34
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
7
7
0
7
0
0
0
7
0
0
0
7
0
54
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
40
47
14
7
14
0
14
0
0
0
0
0
47
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
7
14
0
7
20
14
7
14
14
7
0
7
7
0
% K
% Leu:
7
0
0
7
0
0
0
0
7
7
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
7
0
7
7
0
% N
% Pro:
0
0
27
40
40
0
0
14
34
7
7
14
0
0
0
% P
% Gln:
14
7
0
0
0
20
7
7
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
7
0
0
7
0
0
7
0
0
0
% R
% Ser:
14
0
7
14
20
14
14
27
7
47
14
20
7
7
14
% S
% Thr:
0
0
0
7
0
0
0
7
7
0
40
0
20
7
34
% T
% Val:
0
0
7
0
7
0
0
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _