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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 31.82
Human Site: S175 Identified Species: 50
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 S175 P T R K D Y G S K V S L F S H
Chimpanzee Pan troglodytes XP_515356 522 57373 S174 P T R K D Y G S K V S L F S H
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 G84 P E S G I Q L G T P G E K V P
Dog Lupus familis XP_860642 524 57645 S176 P T R N D Y G S K V S L F S H
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 S176 P T R K D Y G S K V S L F S H
Rat Rattus norvegicus Q63186 524 57791 S176 P T R K D Y G S K V S L F S H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 T200 P L R Q D Y G T K V N L F S H
Frog Xenopus laevis NP_001088928 569 62292 T221 P L R P D Y G T K V S L F S H
Zebra Danio Brachydanio rerio NP_001014383 540 59863 Y192 P L R S D Y G Y K V S L F S H
Tiger Blowfish Takifugu rubipres Q90511 355 39111 T28 L K R G G S G T G P L R G S S
Fruit Fly Dros. melanogaster NP_611790 626 67593 T279 P V K C P A S T P N V D C R V
Honey Bee Apis mellifera XP_001119855 484 53730 E133 K N K V K S K E Q N N N D K S
Nematode Worm Caenorhab. elegans P34604 305 34099
Sea Urchin Strong. purpuratus XP_789710 508 55472 D158 S D D I K L D D P T V Q K R R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 V242 V I P G I S S V I P T V L E Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 6.6 93.3 N.A. 100 100 N.A. N.A. 73.3 80 80 20 6.6 0 0 0
P-Site Similarity: 100 100 6.6 93.3 N.A. 100 100 N.A. N.A. 93.3 86.6 80 26.6 20 20 0 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 7 7 0 54 0 7 7 0 0 0 7 7 0 0 % D
% Glu: 0 7 0 0 0 0 0 7 0 0 0 7 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 54 0 0 % F
% Gly: 0 0 0 20 7 0 60 7 7 0 7 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 54 % H
% Ile: 0 7 0 7 14 0 0 0 7 0 0 0 0 0 0 % I
% Lys: 7 7 14 27 14 0 7 0 54 0 0 0 14 7 0 % K
% Leu: 7 20 0 0 0 7 7 0 0 0 7 54 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 0 0 0 0 0 14 14 7 0 0 0 % N
% Pro: 67 0 7 7 7 0 0 0 14 20 0 0 0 0 7 % P
% Gln: 0 0 0 7 0 7 0 0 7 0 0 7 0 0 7 % Q
% Arg: 0 0 60 0 0 0 0 0 0 0 0 7 0 14 7 % R
% Ser: 7 0 7 7 0 20 14 34 0 0 47 0 0 60 14 % S
% Thr: 0 34 0 0 0 0 0 27 7 7 7 0 0 0 0 % T
% Val: 7 7 0 7 0 0 0 7 0 54 14 7 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 54 0 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _