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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 41.21
Human Site: S272 Identified Species: 64.76
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 S272 Q C R P L S A S M H N A I K F
Chimpanzee Pan troglodytes XP_515356 522 57373 S271 Q C R P L S A S M H N A I K F
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 L178 D Y G S K V S L F S H L P Q Y
Dog Lupus familis XP_860642 524 57645 S273 Q C R P L S A S M Y N A I K F
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 S273 Q C R P M S A S M C N A I K F
Rat Rattus norvegicus Q63186 524 57791 S273 Q C R P M S A S M C N A I K F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 S297 Q C R P L S V S M G N A I K F
Frog Xenopus laevis NP_001088928 569 62292 S318 Q C R P L S A S M G N A I K Y
Zebra Danio Brachydanio rerio NP_001014383 540 59863 S289 Q C R P L S A S M G N A I K Y
Tiger Blowfish Takifugu rubipres Q90511 355 39111 S122 L L T S G G L S E E N F R Q H
Fruit Fly Dros. melanogaster NP_611790 626 67593 S376 K C R P L A V S V S N A Y K Q
Honey Bee Apis mellifera XP_001119855 484 53730 S230 Y C R P L A V S M Q N A M R H
Nematode Worm Caenorhab. elegans P34604 305 34099 L72 S I R S A A D L F T R F T S L
Sea Urchin Strong. purpuratus XP_789710 508 55472 K253 D Y N T P P Q K D L S R D L D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 T339 K A R P L S V T M G N A I R W
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 0 93.3 N.A. 86.6 86.6 N.A. N.A. 86.6 86.6 86.6 13.3 53.3 53.3 6.6 0
P-Site Similarity: 100 100 26.6 100 N.A. 93.3 93.3 N.A. N.A. 86.6 93.3 93.3 20 73.3 73.3 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 7 20 47 0 0 0 0 74 0 0 0 % A
% Cys: 0 67 0 0 0 0 0 0 0 14 0 0 0 0 0 % C
% Asp: 14 0 0 0 0 0 7 0 7 0 0 0 7 0 7 % D
% Glu: 0 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 14 0 0 14 0 0 40 % F
% Gly: 0 0 7 0 7 7 0 0 0 27 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 14 7 0 0 0 14 % H
% Ile: 0 7 0 0 0 0 0 0 0 0 0 0 60 0 0 % I
% Lys: 14 0 0 0 7 0 0 7 0 0 0 0 0 60 0 % K
% Leu: 7 7 0 0 60 0 7 14 0 7 0 7 0 7 7 % L
% Met: 0 0 0 0 14 0 0 0 67 0 0 0 7 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 80 0 0 0 0 % N
% Pro: 0 0 0 74 7 7 0 0 0 0 0 0 7 0 0 % P
% Gln: 54 0 0 0 0 0 7 0 0 7 0 0 0 14 7 % Q
% Arg: 0 0 80 0 0 0 0 0 0 0 7 7 7 14 0 % R
% Ser: 7 0 0 20 0 60 7 74 0 14 7 0 0 7 0 % S
% Thr: 0 0 7 7 0 0 0 7 0 7 0 0 7 0 0 % T
% Val: 0 0 0 0 0 7 27 0 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 7 14 0 0 0 0 0 0 0 7 0 0 7 0 20 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _