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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
5.76
Human Site:
S286
Identified Species:
9.05
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
S286
F
L
N
K
E
I
T
S
V
G
S
S
K
R
E
Chimpanzee
Pan troglodytes
XP_515356
522
57373
S285
F
L
N
K
E
I
T
S
V
G
S
S
K
R
E
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
T192
Y
S
R
Q
N
S
L
T
Q
F
M
S
I
P
S
Dog
Lupus familis
XP_860642
524
57645
G287
F
L
N
K
E
I
T
G
V
S
S
S
K
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
G287
F
L
T
K
E
V
T
G
M
S
S
S
K
R
E
Rat
Rattus norvegicus
Q63186
524
57791
G287
F
F
N
K
E
V
T
G
M
S
S
S
K
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
C311
F
L
K
K
E
I
S
C
L
P
D
T
L
R
E
Frog
Xenopus laevis
NP_001088928
569
62292
N332
Y
I
K
K
E
I
S
N
I
S
Q
S
K
G
E
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
N303
Y
I
K
K
E
I
S
N
I
P
N
Q
C
K
E
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
N136
H
F
A
A
L
R
A
N
V
I
E
A
I
N
E
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
Q390
Q
F
K
N
Q
L
T
Q
L
P
A
D
V
P
E
Honey Bee
Apis mellifera
XP_001119855
484
53730
Q244
H
L
K
W
Q
M
T
Q
F
P
S
S
L
S
D
Nematode Worm
Caenorhab. elegans
P34604
305
34099
D86
L
A
P
A
A
L
L
D
Q
E
D
F
S
Q
V
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
I267
D
Y
K
I
K
P
Y
I
N
F
L
N
Q
C
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
L353
W
L
K
Q
E
I
S
L
I
D
P
S
T
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
6.6
86.6
N.A.
66.6
66.6
N.A.
N.A.
46.6
40
26.6
13.3
13.3
26.6
0
0
P-Site Similarity:
100
100
26.6
86.6
N.A.
80
80
N.A.
N.A.
66.6
73.3
73.3
26.6
40
46.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
14
7
0
7
0
0
0
7
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
7
7
0
% C
% Asp:
7
0
0
0
0
0
0
7
0
7
14
7
0
0
14
% D
% Glu:
0
0
0
0
60
0
0
0
0
7
7
0
0
0
67
% E
% Phe:
40
20
0
0
0
0
0
0
7
14
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
20
0
14
0
0
0
7
0
% G
% His:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
14
0
7
0
47
0
7
20
7
0
0
14
0
0
% I
% Lys:
0
0
47
54
7
0
0
0
0
0
0
0
40
7
0
% K
% Leu:
7
47
0
0
7
14
14
7
14
0
7
0
14
0
0
% L
% Met:
0
0
0
0
0
7
0
0
14
0
7
0
0
0
0
% M
% Asn:
0
0
27
7
7
0
0
20
7
0
7
7
0
7
0
% N
% Pro:
0
0
7
0
0
7
0
0
0
27
7
0
0
20
0
% P
% Gln:
7
0
0
14
14
0
0
14
14
0
7
7
7
7
0
% Q
% Arg:
0
0
7
0
0
7
0
0
0
0
0
0
0
40
7
% R
% Ser:
0
7
0
0
0
7
27
14
0
27
40
60
7
7
7
% S
% Thr:
0
0
7
0
0
0
47
7
0
0
0
7
7
0
0
% T
% Val:
0
0
0
0
0
14
0
0
27
0
0
0
7
0
7
% V
% Trp:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
20
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _