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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 22.73
Human Site: S298 Identified Species: 35.71
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 S298 K R E E E A K S E L R A A I D
Chimpanzee Pan troglodytes XP_515356 522 57373 S297 K R E E E A K S E L R A A I D
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 P204 I P S S V I H P A M V R L G L
Dog Lupus familis XP_860642 524 57645 S299 K R E E E A K S E L R A A I D
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 S299 K R E E E A K S E L K E A L D
Rat Rattus norvegicus Q63186 524 57791 S299 K R E E E A K S E L K E A I D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 E323 L R E E E A K E K L Q G T I D
Frog Xenopus laevis NP_001088928 569 62292 S344 K G E E E A K S D L L S C I D
Zebra Danio Brachydanio rerio NP_001014383 540 59863 G315 C K E E E A K G K L Q A C I D
Tiger Blowfish Takifugu rubipres Q90511 355 39111 L148 I N E L L T E L E G T T D N I
Fruit Fly Dros. melanogaster NP_611790 626 67593 E402 V P E T E S K E L L V H F I D
Honey Bee Apis mellifera XP_001119855 484 53730 N256 L S D V N A K N K L S T A I D
Nematode Worm Caenorhab. elegans P34604 305 34099 R98 S Q V L D L Y R Q R A R S F I
Sea Urchin Strong. purpuratus XP_789710 508 55472 S279 Q C R P K S V S M G N A I K Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 K365 T P D K A A K K D L C E K I G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 0 100 N.A. 80 86.6 N.A. N.A. 60 66.6 60 13.3 40 40 0 13.3
P-Site Similarity: 100 100 6.6 100 N.A. 93.3 93.3 N.A. N.A. 73.3 80 80 20 46.6 60 26.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 67 0 0 7 0 7 34 40 0 0 % A
% Cys: 7 7 0 0 0 0 0 0 0 0 7 0 14 0 0 % C
% Asp: 0 0 14 0 7 0 0 0 14 0 0 0 7 0 67 % D
% Glu: 0 0 67 54 60 0 7 14 40 0 0 20 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 7 0 % F
% Gly: 0 7 0 0 0 0 0 7 0 14 0 7 0 7 7 % G
% His: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 0 % H
% Ile: 14 0 0 0 0 7 0 0 0 0 0 0 7 67 14 % I
% Lys: 40 7 0 7 7 0 74 7 20 0 14 0 7 7 0 % K
% Leu: 14 0 0 14 7 7 0 7 7 74 7 0 7 7 7 % L
% Met: 0 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % M
% Asn: 0 7 0 0 7 0 0 7 0 0 7 0 0 7 0 % N
% Pro: 0 20 0 7 0 0 0 7 0 0 0 0 0 0 0 % P
% Gln: 7 7 0 0 0 0 0 0 7 0 14 0 0 0 0 % Q
% Arg: 0 40 7 0 0 0 0 7 0 7 20 14 0 0 0 % R
% Ser: 7 7 7 7 0 14 0 47 0 0 7 7 7 0 0 % S
% Thr: 7 0 0 7 0 7 0 0 0 0 7 14 7 0 0 % T
% Val: 7 0 7 7 7 0 7 0 0 0 14 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _