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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
12.42
Human Site:
S375
Identified Species:
19.52
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
S375
E
G
R
H
T
L
R
S
L
V
H
A
G
V
P
Chimpanzee
Pan troglodytes
XP_515356
522
57373
S374
E
G
R
H
T
L
R
S
L
V
H
A
G
V
P
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
K281
N
A
I
K
F
L
N
K
E
I
T
S
V
G
S
Dog
Lupus familis
XP_860642
524
57645
S376
E
G
R
H
T
L
R
S
L
V
R
A
G
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
S376
E
G
R
H
M
L
H
S
L
V
R
A
G
V
P
Rat
Rattus norvegicus
Q63186
524
57791
C376
E
G
R
H
M
L
H
C
L
V
R
A
G
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
R400
L
E
G
R
E
T
L
R
R
L
V
R
H
G
I
Frog
Xenopus laevis
NP_001088928
569
62292
R421
E
G
R
E
T
L
R
R
L
V
N
C
G
I
H
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
R392
E
G
R
E
A
L
R
R
L
V
K
K
G
I
R
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
A225
T
T
V
I
A
D
A
A
I
F
A
V
M
S
R
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
R479
E
G
Q
E
L
L
R
R
L
H
A
T
G
I
P
Honey Bee
Apis mellifera
XP_001119855
484
53730
R333
E
G
K
E
Q
L
R
R
L
S
R
H
G
I
E
Nematode Worm
Caenorhab. elegans
P34604
305
34099
N175
V
F
E
E
L
K
K
N
G
V
P
T
T
L
V
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
D356
L
I
R
K
V
L
C
D
A
H
K
S
G
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
E442
F
E
G
R
K
M
A
E
T
L
R
N
A
G
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
6.6
93.3
N.A.
80
73.3
N.A.
N.A.
0
60
53.3
0
46.6
40
6.6
20
P-Site Similarity:
100
100
20
93.3
N.A.
80
73.3
N.A.
N.A.
6.6
73.3
60
13.3
60
53.3
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
14
0
14
7
7
0
14
34
7
0
0
% A
% Cys:
0
0
0
0
0
0
7
7
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% D
% Glu:
60
14
7
34
7
0
0
7
7
0
0
0
0
0
7
% E
% Phe:
7
7
0
0
7
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
60
14
0
0
0
0
0
7
0
0
0
67
20
0
% G
% His:
0
0
0
34
0
0
14
0
0
14
14
7
7
0
7
% H
% Ile:
0
7
7
7
0
0
0
0
7
7
0
0
0
34
7
% I
% Lys:
0
0
7
14
7
7
7
7
0
0
14
7
0
0
0
% K
% Leu:
14
0
0
0
14
74
7
0
60
14
0
0
0
7
0
% L
% Met:
0
0
0
0
14
7
0
0
0
0
0
0
7
0
0
% M
% Asn:
7
0
0
0
0
0
7
7
0
0
7
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
40
% P
% Gln:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
54
14
0
0
47
34
7
0
34
7
0
0
14
% R
% Ser:
0
0
0
0
0
0
0
27
0
7
0
14
0
7
14
% S
% Thr:
7
7
0
0
27
7
0
0
7
0
7
14
7
0
0
% T
% Val:
7
0
7
0
7
0
0
0
0
54
7
7
7
34
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _