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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
34.24
Human Site:
S399
Identified Species:
53.81
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
S399
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Chimpanzee
Pan troglodytes
XP_515356
522
57373
S398
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
R305
E
L
Q
A
A
I
D
R
Y
V
K
E
K
I
V
Dog
Lupus familis
XP_860642
524
57645
S400
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
S400
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Rat
Rattus norvegicus
Q63186
524
57791
S400
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
V424
I
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
Frog
Xenopus laevis
NP_001088928
569
62292
S445
S
Y
I
L
P
E
V
S
K
V
F
L
G
A
H
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
S416
S
Y
I
L
P
E
V
S
K
V
F
L
G
A
H
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
L249
T
V
L
A
N
G
G
L
R
A
V
N
G
T
H
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
T503
G
Y
V
M
A
E
A
T
K
V
L
L
G
A
H
Honey Bee
Apis mellifera
XP_001119855
484
53730
S357
S
Y
V
M
S
E
V
S
K
V
F
L
G
A
H
Nematode Worm
Caenorhab. elegans
P34604
305
34099
V199
E
R
I
Q
A
V
L
V
G
A
E
G
V
M
E
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
G380
P
K
V
E
G
R
E
G
I
R
R
L
V
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
D466
L
D
T
I
F
N
M
D
V
D
Y
V
F
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
N.A.
6.6
86.6
86.6
13.3
66.6
80
0
20
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
N.A.
20
93.3
93.3
40
80
86.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
20
0
7
0
0
14
0
0
0
67
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
7
7
0
7
0
0
0
0
0
% D
% Glu:
14
0
0
7
0
60
14
0
0
0
7
7
0
0
7
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
20
0
7
0
0
% F
% Gly:
7
0
0
0
7
7
7
7
7
0
0
7
67
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% H
% Ile:
7
0
20
7
0
7
0
0
7
0
0
0
0
7
0
% I
% Lys:
0
7
0
0
0
0
0
0
60
7
7
0
7
0
0
% K
% Leu:
7
7
7
47
7
0
7
7
0
0
40
74
7
7
0
% L
% Met:
0
0
0
14
0
0
7
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
7
7
0
0
0
0
0
7
0
0
0
% N
% Pro:
7
0
0
0
47
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
7
0
7
7
7
7
0
0
0
0
% R
% Ser:
54
7
0
0
7
0
0
54
7
0
0
0
0
0
0
% S
% Thr:
7
0
7
0
0
0
0
7
0
0
0
0
0
7
0
% T
% Val:
0
7
54
7
0
7
54
14
7
67
14
7
14
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
60
7
0
0
0
0
0
7
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _