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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 33.64
Human Site: S481 Identified Species: 52.86
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 S481 A N W Q N H A S L R L L N L V
Chimpanzee Pan troglodytes XP_515356 522 57373 S480 A N W Q N H A S L R L L N L V
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 H370 R P R L E G R H T L H S L V R
Dog Lupus familis XP_860642 524 57645 S482 A N W Q N H L S L R L L N L V
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 S482 A N W Q S H P S L R L L N L V
Rat Rattus norvegicus Q63186 524 57791 S482 A N W Q N N S S L R L L N L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 S507 G G W A E N K S L R L L N L V
Frog Xenopus laevis NP_001088928 569 62292 S527 R N W Q K N S S L R L L N L V
Zebra Danio Brachydanio rerio NP_001014383 540 59863 S498 E N W Q T V K S L G L L N L V
Tiger Blowfish Takifugu rubipres Q90511 355 39111 C314 L S K V N V H C P V F D Y V P
Fruit Fly Dros. melanogaster NP_611790 626 67593 K583 S N W A A K G K L L P L N L S
Honey Bee Apis mellifera XP_001119855 484 53730 S442 S N W K T K K S L N L L N I M
Nematode Worm Caenorhab. elegans P34604 305 34099 N264 R T S V I E R N N L E L E H P
Sea Urchin Strong. purpuratus XP_789710 508 55472 A466 A D W R D I N A L T L L N L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 S609 D G W Q E L P S L N I V N I L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 0 93.3 N.A. 86.6 86.6 N.A. N.A. 60 73.3 66.6 6.6 40 46.6 6.6 53.3
P-Site Similarity: 100 100 6.6 93.3 N.A. 93.3 100 N.A. N.A. 66.6 86.6 66.6 20 46.6 73.3 13.3 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 0 14 7 0 14 7 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 7 0 0 0 0 0 0 7 0 0 0 % D
% Glu: 7 0 0 0 20 7 0 0 0 0 7 0 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 7 14 0 0 0 7 7 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 27 7 7 0 0 7 0 0 7 0 % H
% Ile: 0 0 0 0 7 7 0 0 0 0 7 0 0 14 0 % I
% Lys: 0 0 7 7 7 14 20 7 0 0 0 0 0 0 0 % K
% Leu: 7 0 0 7 0 7 7 0 80 20 67 80 7 67 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 60 0 0 34 20 7 7 7 14 0 0 80 0 0 % N
% Pro: 0 7 0 0 0 0 14 0 7 0 7 0 0 0 14 % P
% Gln: 0 0 0 54 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 20 0 7 7 0 0 14 0 0 47 0 0 0 0 7 % R
% Ser: 14 7 7 0 7 0 14 67 0 0 0 7 0 0 7 % S
% Thr: 0 7 0 0 14 0 0 0 7 7 0 0 0 0 0 % T
% Val: 0 0 0 14 0 14 0 0 0 7 0 7 0 14 60 % V
% Trp: 0 0 80 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _