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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 20.3
Human Site: T133 Identified Species: 31.9
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 T133 P P K A S P S T A G E T P S G
Chimpanzee Pan troglodytes XP_515356 522 57373 T132 P P K A S P S T A G E T P S G
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 K49 E K K Q Q K K K R K E E K G A
Dog Lupus familis XP_860642 524 57645 T133 P P R A C P S T A G E T P S G
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 T133 P P Q A C P S T A G E T T S G
Rat Rattus norvegicus Q63186 524 57791 T133 S P Q A C P S T A G E A T S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 T157 A P A K P R L T P T E A P S V
Frog Xenopus laevis NP_001088928 569 62292 A178 P G Q G K A K A V S I E G Q T
Zebra Danio Brachydanio rerio NP_001014383 540 59863 S149 T S S K P K A S P N E L Q P V
Tiger Blowfish Takifugu rubipres Q90511 355 39111
Fruit Fly Dros. melanogaster NP_611790 626 67593 P203 P V A A S A A P S T T E A D Q
Honey Bee Apis mellifera XP_001119855 484 53730 N96 S S I S E T S N E G K S K A E
Nematode Worm Caenorhab. elegans P34604 305 34099
Sea Urchin Strong. purpuratus XP_789710 508 55472 S123 G G S S S L P S S G S S G Q L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 A199 L S A G T S S A S T N T P T A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 13.3 86.6 N.A. 80 66.6 N.A. N.A. 33.3 6.6 6.6 0 20 13.3 0 13.3
P-Site Similarity: 100 100 13.3 93.3 N.A. 86.6 73.3 N.A. N.A. 33.3 13.3 20 0 33.3 40 0 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 20 40 0 14 14 14 34 0 0 14 7 7 14 % A
% Cys: 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % D
% Glu: 7 0 0 0 7 0 0 0 7 0 54 20 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 14 0 14 0 0 0 0 0 47 0 0 14 7 34 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 0 % I
% Lys: 0 7 20 14 7 14 14 7 0 7 7 0 14 0 0 % K
% Leu: 7 0 0 0 0 7 7 0 0 0 0 7 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 0 7 7 0 0 0 0 % N
% Pro: 40 40 0 0 14 34 7 7 14 0 0 0 34 7 0 % P
% Gln: 0 0 20 7 7 0 0 0 0 0 0 0 7 14 7 % Q
% Arg: 0 0 7 0 0 7 0 0 7 0 0 0 0 0 0 % R
% Ser: 14 20 14 14 27 7 47 14 20 7 7 14 0 40 0 % S
% Thr: 7 0 0 0 7 7 0 40 0 20 7 34 14 7 7 % T
% Val: 0 7 0 0 0 0 0 0 7 0 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _