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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
17.88
Human Site:
T169
Identified Species:
28.1
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
T169
P
E
R
Q
Q
V
P
T
R
K
D
Y
G
S
K
Chimpanzee
Pan troglodytes
XP_515356
522
57373
T168
P
E
R
Q
Q
V
P
T
R
K
D
Y
G
S
K
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
E78
G
P
T
R
E
L
P
E
S
G
I
Q
L
G
T
Dog
Lupus familis
XP_860642
524
57645
T170
P
E
Q
Q
Q
V
P
T
R
N
D
Y
G
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
T170
P
D
R
Q
Q
V
P
T
R
K
D
Y
G
S
K
Rat
Rattus norvegicus
Q63186
524
57791
T170
P
D
R
Q
Q
V
P
T
R
K
D
Y
G
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
L194
L
E
R
Q
Q
V
P
L
R
Q
D
Y
G
T
K
Frog
Xenopus laevis
NP_001088928
569
62292
L215
L
E
R
Q
Q
V
P
L
R
P
D
Y
G
T
K
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
L186
L
E
R
Q
Q
V
P
L
R
S
D
Y
G
Y
K
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
K22
E
A
F
L
S
D
L
K
R
G
G
S
G
T
G
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
V273
A
A
T
S
S
S
P
V
K
C
P
A
S
T
P
Honey Bee
Apis mellifera
XP_001119855
484
53730
N127
Q
Q
I
L
L
E
K
N
K
V
K
S
K
E
Q
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
D152
K
D
I
Y
R
V
S
D
D
I
K
L
D
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
I236
E
A
G
E
F
N
V
I
P
G
I
S
S
V
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
6.6
86.6
N.A.
93.3
93.3
N.A.
N.A.
73.3
73.3
73.3
13.3
6.6
0
0
6.6
P-Site Similarity:
100
100
26.6
93.3
N.A.
100
100
N.A.
N.A.
86.6
80
73.3
20
20
20
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
20
0
0
0
0
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
20
0
0
0
7
0
7
7
0
54
0
7
7
0
% D
% Glu:
14
40
0
7
7
7
0
7
0
0
0
0
0
7
0
% E
% Phe:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
20
7
0
60
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
14
0
0
0
0
7
0
7
14
0
0
0
7
% I
% Lys:
7
0
0
0
0
0
7
7
14
27
14
0
7
0
54
% K
% Leu:
20
0
0
14
7
7
7
20
0
0
0
7
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
7
0
7
0
0
0
0
0
% N
% Pro:
34
7
0
0
0
0
67
0
7
7
7
0
0
0
14
% P
% Gln:
7
7
7
54
54
0
0
0
0
7
0
7
0
0
7
% Q
% Arg:
0
0
47
7
7
0
0
0
60
0
0
0
0
0
0
% R
% Ser:
0
0
0
7
14
7
7
0
7
7
0
20
14
34
0
% S
% Thr:
0
0
14
0
0
0
0
34
0
0
0
0
0
27
7
% T
% Val:
0
0
0
0
0
60
7
7
0
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
54
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _