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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 32.12
Human Site: T241 Identified Species: 50.48
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 T241 Q Q V I Q D Y T T P P N E E L
Chimpanzee Pan troglodytes XP_515356 522 57373 T240 Q Q V I Q D Y T T P P N E E L
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 P147 V K R L P E Y P Q V D D L L L
Dog Lupus familis XP_860642 524 57645 T242 Q Q V I Q D Y T T P P N E E L
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 T242 Q Q V I Q D Y T T P P S E E L
Rat Rattus norvegicus Q63186 524 57791 T242 Q Q V I Q D Y T T P P N E E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 S266 K Q L I R D Y S T P P N E E L
Frog Xenopus laevis NP_001088928 569 62292 T287 K Q V I R D Y T T P Q Q E E L
Zebra Danio Brachydanio rerio NP_001014383 540 59863 S258 K Q V I Q D Y S T P P N E E L
Tiger Blowfish Takifugu rubipres Q90511 355 39111 I91 M I R R V L K I I R E E Y A R
Fruit Fly Dros. melanogaster NP_611790 626 67593 E345 R Q V V H D F E T P A K K E F
Honey Bee Apis mellifera XP_001119855 484 53730 E199 K Q L I Y D F E R P P Q A D F
Nematode Worm Caenorhab. elegans P34604 305 34099 T41 L D R S R A T T V A E F Q N E
Sea Urchin Strong. purpuratus XP_789710 508 55472 A222 I K L G L Q Y A E G I I S G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 Q308 Q I V I K D Y Q T P K G T T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 13.3 100 N.A. 93.3 100 N.A. N.A. 73.3 73.3 86.6 0 40 33.3 6.6 6.6
P-Site Similarity: 100 100 40 100 N.A. 100 100 N.A. N.A. 100 86.6 100 0 66.6 60 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 7 0 7 7 0 7 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 74 0 0 0 0 7 7 0 7 0 % D
% Glu: 0 0 0 0 0 7 0 14 7 0 14 7 54 60 7 % E
% Phe: 0 0 0 0 0 0 14 0 0 0 0 7 0 0 14 % F
% Gly: 0 0 0 7 0 0 0 0 0 7 0 7 0 7 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 14 0 67 0 0 0 7 7 0 7 7 0 0 0 % I
% Lys: 27 14 0 0 7 0 7 0 0 0 7 7 7 0 0 % K
% Leu: 7 0 20 7 7 7 0 0 0 0 0 0 7 7 67 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 40 0 7 0 % N
% Pro: 0 0 0 0 7 0 0 7 0 74 54 0 0 0 0 % P
% Gln: 40 67 0 0 40 7 0 7 7 0 7 14 7 0 0 % Q
% Arg: 7 0 20 7 20 0 0 0 7 7 0 0 0 0 7 % R
% Ser: 0 0 0 7 0 0 0 14 0 0 0 7 7 0 0 % S
% Thr: 0 0 0 0 0 0 7 47 67 0 0 0 7 7 0 % T
% Val: 7 0 60 7 7 0 0 0 7 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 74 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _