KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
30.61
Human Site:
T32
Identified Species:
48.1
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
T32
G
A
V
G
R
E
M
T
K
E
E
K
L
Q
L
Chimpanzee
Pan troglodytes
XP_515356
522
57373
T32
G
A
V
G
R
E
M
T
K
E
E
K
L
Q
L
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
Dog
Lupus familis
XP_860642
524
57645
T32
G
A
V
G
R
E
M
T
Q
E
E
K
L
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
T32
G
A
A
G
R
E
L
T
Q
E
E
K
L
Q
L
Rat
Rattus norvegicus
Q63186
524
57791
T32
G
A
A
G
R
E
L
T
Q
E
E
K
L
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
S52
V
V
Q
G
P
E
L
S
R
E
E
K
L
Q
L
Frog
Xenopus laevis
NP_001088928
569
62292
S33
K
G
E
G
Q
E
M
S
K
E
E
K
L
R
L
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
T36
K
S
E
G
K
E
L
T
K
E
E
K
Q
R
L
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
T61
N
A
V
D
P
L
A
T
E
K
T
R
D
Q
I
Honey Bee
Apis mellifera
XP_001119855
484
53730
A25
A
E
R
E
A
K
K
A
A
K
A
H
A
K
A
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
G36
G
D
A
G
G
E
G
G
E
K
K
L
S
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
R80
K
E
K
K
Q
L
Q
R
E
Q
Q
Q
K
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
0
93.3
N.A.
80
80
N.A.
N.A.
53.3
60
53.3
0
26.6
0
0
20
P-Site Similarity:
100
100
0
100
N.A.
93.3
93.3
N.A.
N.A.
73.3
80
80
0
53.3
20
0
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
40
20
0
7
0
7
7
7
0
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
7
0
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
14
14
7
0
60
0
0
20
54
54
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
40
7
0
60
7
0
7
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
20
0
7
7
7
7
7
0
27
20
7
54
7
14
7
% K
% Leu:
0
0
0
0
0
14
27
0
0
0
0
7
47
0
54
% L
% Met:
0
0
0
0
0
0
27
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
14
0
7
0
20
7
7
7
7
47
0
% Q
% Arg:
0
0
7
0
34
0
0
7
7
0
0
7
0
20
0
% R
% Ser:
0
7
0
0
0
0
0
14
0
0
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
47
0
0
7
0
0
0
0
% T
% Val:
7
7
27
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _