KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
10.3
Human Site:
T351
Identified Species:
16.19
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
T351
R
I
L
Q
E
A
W
T
E
G
R
R
F
R
V
Chimpanzee
Pan troglodytes
XP_515356
522
57373
T350
R
I
L
Q
E
A
W
T
E
G
R
R
F
R
V
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
P257
D
L
V
N
K
L
K
P
Y
M
S
F
L
T
Q
Dog
Lupus familis
XP_860642
524
57645
A352
R
I
L
Q
E
A
W
A
K
G
R
R
F
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
V352
R
I
L
Q
E
A
R
V
E
G
R
R
F
R
V
Rat
Rattus norvegicus
Q63186
524
57791
V352
R
I
L
Q
E
A
W
V
E
G
R
R
F
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
T376
R
T
L
C
D
A
H
T
Q
T
D
R
T
F
R
Frog
Xenopus laevis
NP_001088928
569
62292
R397
C
T
L
Q
E
A
H
R
N
G
K
K
F
R
V
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
E368
H
I
L
C
E
A
F
E
K
Q
R
Q
F
R
V
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
F201
I
V
A
E
C
A
P
F
C
Q
G
H
K
M
A
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
R455
F
I
C
E
E
A
K
R
R
Q
V
A
F
R
V
Honey Bee
Apis mellifera
XP_001119855
484
53730
T309
K
I
L
L
D
A
H
T
A
G
K
Q
F
R
V
Nematode Worm
Caenorhab. elegans
P34604
305
34099
H151
D
A
H
K
S
G
Y
H
L
H
V
W
V
T
E
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
C332
A
I
S
K
T
F
A
C
K
K
I
R
D
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
I418
E
L
L
L
H
N
A
I
S
L
K
K
N
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
0
86.6
N.A.
86.6
93.3
N.A.
N.A.
33.3
53.3
53.3
6.6
40
53.3
0
13.3
P-Site Similarity:
100
100
20
93.3
N.A.
86.6
93.3
N.A.
N.A.
46.6
66.6
73.3
20
46.6
80
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
0
0
74
14
7
7
0
0
7
0
0
7
% A
% Cys:
7
0
7
14
7
0
0
7
7
0
0
0
0
0
0
% C
% Asp:
14
0
0
0
14
0
0
0
0
0
7
0
7
0
7
% D
% Glu:
7
0
0
14
54
0
0
7
27
0
0
0
0
0
7
% E
% Phe:
7
0
0
0
0
7
7
7
0
0
0
7
60
7
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
47
7
0
0
7
0
% G
% His:
7
0
7
0
7
0
20
7
0
7
0
7
0
0
0
% H
% Ile:
7
60
0
0
0
0
0
7
0
0
7
0
0
7
0
% I
% Lys:
7
0
0
14
7
0
14
0
20
7
20
14
7
0
7
% K
% Leu:
0
14
67
14
0
7
0
0
7
7
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% M
% Asn:
0
0
0
7
0
7
0
0
7
0
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
40
0
0
0
0
7
20
0
14
0
0
7
% Q
% Arg:
40
0
0
0
0
0
7
14
7
0
40
47
0
60
7
% R
% Ser:
0
0
7
0
7
0
0
0
7
0
7
0
0
0
0
% S
% Thr:
0
14
0
0
7
0
0
27
0
7
0
0
7
14
0
% T
% Val:
0
7
7
0
0
0
0
14
0
0
14
0
7
0
60
% V
% Trp:
0
0
0
0
0
0
27
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _