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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
16.06
Human Site:
T86
Identified Species:
25.24
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
T86
E
S
G
I
Q
L
G
T
P
R
E
K
V
P
A
Chimpanzee
Pan troglodytes
XP_515356
522
57373
T85
E
S
G
I
Q
L
G
T
P
G
E
K
V
P
A
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
R21
S
G
M
K
A
E
L
R
P
G
P
G
A
V
G
Dog
Lupus familis
XP_860642
524
57645
T86
G
P
G
S
Q
L
A
T
A
G
E
K
V
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
T86
P
G
S
Q
L
G
G
T
A
G
E
K
L
P
A
Rat
Rattus norvegicus
Q63186
524
57791
T86
T
G
S
Q
L
G
G
T
T
G
E
K
L
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
N109
P
A
S
A
N
A
P
N
D
G
E
K
P
P
G
Frog
Xenopus laevis
NP_001088928
569
62292
S143
T
G
G
G
K
S
K
S
E
L
R
A
E
R
R
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
T102
V
T
A
S
A
S
E
T
P
A
A
A
E
K
P
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
N144
T
T
Q
P
A
A
V
N
G
K
D
A
E
A
G
Honey Bee
Apis mellifera
XP_001119855
484
53730
T66
S
N
E
T
S
K
T
T
T
N
E
N
I
E
S
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
A77
K
S
K
A
E
M
K
A
E
R
R
A
R
Q
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
T158
L
S
G
S
N
V
L
T
A
S
S
L
M
P
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
93.3
6.6
53.3
N.A.
40
40
N.A.
N.A.
20
6.6
13.3
0
0
13.3
0
13.3
P-Site Similarity:
100
93.3
6.6
53.3
N.A.
46.6
46.6
N.A.
N.A.
26.6
20
20
0
20
33.3
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
14
20
14
7
7
20
7
7
27
7
7
27
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% D
% Glu:
14
0
7
0
7
7
7
0
14
0
47
0
20
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
27
34
7
0
14
27
0
7
40
0
7
0
0
20
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
14
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
7
0
7
7
7
7
14
0
0
7
0
40
0
7
0
% K
% Leu:
7
0
0
0
14
20
14
0
0
7
0
7
14
0
0
% L
% Met:
0
0
7
0
0
7
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
7
0
0
14
0
0
14
0
7
0
7
0
0
0
% N
% Pro:
14
7
0
7
0
0
7
0
27
0
7
0
7
47
7
% P
% Gln:
0
0
7
14
20
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
0
0
0
0
0
0
7
0
14
14
0
7
7
7
% R
% Ser:
14
27
20
20
7
14
0
7
0
7
7
0
0
0
7
% S
% Thr:
20
14
0
7
0
0
7
54
14
0
0
0
0
0
7
% T
% Val:
7
0
0
0
0
7
7
0
0
0
0
0
20
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _