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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B4 All Species: 29.7
Human Site: Y186 Identified Species: 46.67
UniProt: Q9UI10 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UI10 NP_001029288.1 523 57557 Y186 L F S H L P Q Y S R Q N S L T
Chimpanzee Pan troglodytes XP_515356 522 57373 Y185 L F S H L P Q Y S R Q N S L T
Rhesus Macaque Macaca mulatta XP_001094256 411 45254 S95 E K V P A G R S K A E L R A E
Dog Lupus familis XP_860642 524 57645 Y187 L F S H L P Q Y S R Q N S L T
Cat Felis silvestris
Mouse Mus musculus Q61749 524 57578 Y187 L F S H L P Q Y S R Q S S L T
Rat Rattus norvegicus Q63186 524 57791 Y187 L F S H L P Q Y S R Q S S L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423512 550 60270 Y211 L F S H L H Q Y S R K K P L T
Frog Xenopus laevis NP_001088928 569 62292 Y232 L F S H L H Q Y S R K L P L T
Zebra Danio Brachydanio rerio NP_001014383 540 59863 Y203 L F S H L H Q Y S R K N P P T
Tiger Blowfish Takifugu rubipres Q90511 355 39111 R39 R G S S E T A R E T T A L L R
Fruit Fly Dros. melanogaster NP_611790 626 67593 N290 D C R V K L F N H L V C A K E
Honey Bee Apis mellifera XP_001119855 484 53730 E144 N D K S V I T E T V K K I A I
Nematode Worm Caenorhab. elegans P34604 305 34099
Sea Urchin Strong. purpuratus XP_789710 508 55472 L169 Q K R R A K K L E R Q Q V P Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P12754 651 70834 N253 V L E Q S F D N S S L I S S V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 76 91.5 N.A. 87.4 87.4 N.A. N.A. 64.9 59.5 61.1 20.6 36.7 39.9 21.4 41.6
Protein Similarity: 100 99.4 77 93.8 N.A. 91.9 92.1 N.A. N.A. 76.1 71.5 74.2 38.8 52.8 58.5 35.1 57.9
P-Site Identity: 100 100 0 100 N.A. 93.3 93.3 N.A. N.A. 73.3 73.3 73.3 13.3 0 0 0 13.3
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. N.A. 80 80 80 13.3 6.6 20 0 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 14 0 7 0 0 7 0 7 7 14 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 7 7 0 0 0 0 7 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 7 0 7 0 0 7 14 0 7 0 0 0 14 % E
% Phe: 0 54 0 0 0 7 7 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 0 0 0 7 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 54 0 20 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 0 0 0 0 0 7 7 0 7 % I
% Lys: 0 14 7 0 7 7 7 0 7 0 27 14 0 7 0 % K
% Leu: 54 7 0 0 54 7 0 7 0 7 7 14 7 54 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 14 0 0 0 27 0 0 0 % N
% Pro: 0 0 0 7 0 34 0 0 0 0 0 0 20 14 0 % P
% Gln: 7 0 0 7 0 0 54 0 0 0 40 7 0 0 7 % Q
% Arg: 7 0 14 7 0 0 7 7 0 60 0 0 7 0 7 % R
% Ser: 0 0 60 14 7 0 0 7 60 7 0 14 40 7 0 % S
% Thr: 0 0 0 0 0 7 7 0 7 7 7 0 0 0 54 % T
% Val: 7 0 7 7 7 0 0 0 0 7 7 0 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 54 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _