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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B4
All Species:
20
Human Site:
Y324
Identified Species:
31.43
UniProt:
Q9UI10
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UI10
NP_001029288.1
523
57557
Y324
Q
A
I
S
R
F
A
Y
Q
K
I
S
N
G
D
Chimpanzee
Pan troglodytes
XP_515356
522
57373
Y323
Q
A
I
S
R
F
A
Y
Q
K
I
S
N
G
D
Rhesus Macaque
Macaca mulatta
XP_001094256
411
45254
R230
A
R
C
I
A
L
L
R
A
L
Q
Q
V
I
Q
Dog
Lupus familis
XP_860642
524
57645
Y325
Q
A
I
S
R
F
A
Y
K
K
I
N
N
G
D
Cat
Felis silvestris
Mouse
Mus musculus
Q61749
524
57578
S325
Q
A
I
S
R
F
A
S
T
K
I
S
D
G
D
Rat
Rattus norvegicus
Q63186
524
57791
S325
Q
A
I
S
R
F
A
S
K
K
I
S
D
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423512
550
60270
F349
E
A
I
S
K
S
A
F
E
K
I
N
D
N
D
Frog
Xenopus laevis
NP_001088928
569
62292
A370
E
A
I
S
K
S
A
A
E
K
I
S
E
D
D
Zebra Danio
Brachydanio rerio
NP_001014383
540
59863
I341
E
A
I
S
K
Y
A
I
E
K
I
S
N
G
D
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
R174
E
V
I
M
T
V
G
R
S
R
T
V
E
A
F
Fruit Fly
Dros. melanogaster
NP_611790
626
67593
Q428
Q
A
I
S
G
F
L
Q
E
K
I
T
D
G
D
Honey Bee
Apis mellifera
XP_001119855
484
53730
Q282
K
A
I
S
I
T
I
Q
T
K
I
S
N
G
D
Nematode Worm
Caenorhab. elegans
P34604
305
34099
T124
K
C
A
R
L
F
F
T
H
H
M
N
I
L
T
Sea Urchin
Strong. purpuratus
XP_789710
508
55472
Q305
M
P
D
K
E
A
K
Q
R
L
C
D
C
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P12754
651
70834
S391
Q
L
I
I
D
N
A
S
T
Q
I
E
E
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
76
91.5
N.A.
87.4
87.4
N.A.
N.A.
64.9
59.5
61.1
20.6
36.7
39.9
21.4
41.6
Protein Similarity:
100
99.4
77
93.8
N.A.
91.9
92.1
N.A.
N.A.
76.1
71.5
74.2
38.8
52.8
58.5
35.1
57.9
P-Site Identity:
100
100
0
86.6
N.A.
80
80
N.A.
N.A.
46.6
53.3
66.6
6.6
60
60
6.6
6.6
P-Site Similarity:
100
100
0
100
N.A.
86.6
93.3
N.A.
N.A.
86.6
73.3
93.3
20
80
66.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
67
7
0
7
7
60
7
7
0
0
0
0
7
0
% A
% Cys:
0
7
7
0
0
0
0
0
0
0
7
0
7
0
0
% C
% Asp:
0
0
7
0
7
0
0
0
0
0
0
7
27
7
74
% D
% Glu:
27
0
0
0
7
0
0
0
27
0
0
7
20
0
0
% E
% Phe:
0
0
0
0
0
47
7
7
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
7
0
7
0
0
0
0
0
0
54
0
% G
% His:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% H
% Ile:
0
0
80
14
7
0
7
7
0
0
74
0
7
14
0
% I
% Lys:
14
0
0
7
20
0
7
0
14
67
0
0
0
0
0
% K
% Leu:
0
7
0
0
7
7
14
0
0
14
0
0
0
7
0
% L
% Met:
7
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
0
0
0
20
34
7
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
47
0
0
0
0
0
0
20
14
7
7
7
0
0
7
% Q
% Arg:
0
7
0
7
34
0
0
14
7
7
0
0
0
0
0
% R
% Ser:
0
0
0
67
0
14
0
20
7
0
0
47
0
7
0
% S
% Thr:
0
0
0
0
7
7
0
7
20
0
7
7
0
0
14
% T
% Val:
0
7
0
0
0
7
0
0
0
0
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
20
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _