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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MUTYH All Species: 23.94
Human Site: S256 Identified Species: 47.88
UniProt: Q9UIF7 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UIF7 NP_001041636.1 546 60069 S256 D P S S T L V S Q Q L W G L A
Chimpanzee Pan troglodytes XP_001155767 546 60211 S256 D P S S T L V S Q Q L W G L A
Rhesus Macaque Macaca mulatta XP_001101469 533 58769 S242 D P S S T L V S Q R L W G L A
Dog Lupus familis XP_539632 573 63255 S282 D S S S T L V S Q H L W G L A
Cat Felis silvestris
Mouse Mus musculus Q99P21 515 57711 S230 D P T S T L V S H H L W N L A
Rat Rattus norvegicus Q8R5G2 516 57901 S230 D P T S S F V S H H L W D L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519000 605 64943 S251 D P S S P V V S Q Q L W S L A
Chicken Gallus gallus XP_422433 511 56150 D233 D M A N T L V D R S R P G D F
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_686698 526 59141 L225 S P A V T D A L W R I A D A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791369 425 47583 F166 D P D R P G D F N Q S M M E L
Poplar Tree Populus trichocarpa XP_002321221 480 54779 V220 N P K D K V T V K K F W K L A
Maize Zea mays NP_001150481 469 52213 K210 Y T I A D N P K E S S T V K R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 92.8 76.7 N.A. 73.4 73 N.A. 54.7 55.3 N.A. 46.1 N.A. N.A. N.A. N.A. 37.1
Protein Similarity: 100 99.6 94.6 83.4 N.A. 81.1 80.7 N.A. 64.9 67.2 N.A. 60.2 N.A. N.A. N.A. N.A. 49.4
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 60 N.A. 80 33.3 N.A. 13.3 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 100 100 86.6 N.A. 80 73.3 N.A. 86.6 53.3 N.A. 33.3 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: 33.7 32.4 N.A. N.A. N.A. N.A.
Protein Similarity: 49.6 48.9 N.A. N.A. N.A. N.A.
P-Site Identity: 26.6 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 53.3 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 9 0 0 9 0 0 0 0 9 0 9 67 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 75 0 9 9 9 9 9 9 0 0 0 0 17 9 0 % D
% Glu: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % E
% Phe: 0 0 0 0 0 9 0 9 0 0 9 0 0 0 9 % F
% Gly: 0 0 0 0 0 9 0 0 0 0 0 0 42 0 0 % G
% His: 0 0 0 0 0 0 0 0 17 25 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 9 0 0 0 0 % I
% Lys: 0 0 9 0 9 0 0 9 9 9 0 0 9 9 0 % K
% Leu: 0 0 0 0 0 50 0 9 0 0 59 0 0 67 17 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 9 9 0 0 % M
% Asn: 9 0 0 9 0 9 0 0 9 0 0 0 9 0 0 % N
% Pro: 0 75 0 0 17 0 9 0 0 0 0 9 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 42 34 0 0 0 0 0 % Q
% Arg: 0 0 0 9 0 0 0 0 9 17 9 0 0 0 9 % R
% Ser: 9 9 42 59 9 0 0 59 0 17 17 0 9 0 0 % S
% Thr: 0 9 17 0 59 0 9 0 0 0 0 9 0 0 0 % T
% Val: 0 0 0 9 0 17 67 9 0 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 9 0 0 67 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _