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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MUTYH
All Species:
22.73
Human Site:
Y494
Identified Species:
45.45
UniProt:
Q9UIF7
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIF7
NP_001041636.1
546
60069
Y494
M
K
K
V
F
R
V
Y
Q
G
Q
Q
P
G
T
Chimpanzee
Pan troglodytes
XP_001155767
546
60211
Y494
M
K
K
V
F
R
V
Y
Q
G
Q
Q
P
G
T
Rhesus Macaque
Macaca mulatta
XP_001101469
533
58769
Y481
M
K
K
V
F
R
V
Y
Q
G
Q
Q
P
G
T
Dog
Lupus familis
XP_539632
573
63255
Y521
M
K
K
V
F
R
V
Y
E
G
Q
Q
P
G
I
Cat
Felis silvestris
Mouse
Mus musculus
Q99P21
515
57711
Y465
M
K
K
V
F
R
M
Y
E
D
H
R
Q
G
T
Rat
Rattus norvegicus
Q8R5G2
516
57901
Y466
M
K
K
V
F
R
V
Y
E
E
H
R
R
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519000
605
64943
E499
K
K
V
F
R
M
Y
E
G
R
Q
P
G
G
K
Chicken
Gallus gallus
XP_422433
511
56150
S455
E
F
R
A
S
A
V
S
T
A
M
K
K
V
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_686698
526
59141
E470
K
K
I
M
K
L
Y
E
S
S
S
K
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791369
425
47583
I376
K
S
Q
E
S
E
D
I
P
H
H
Q
W
V
S
Poplar Tree
Populus trichocarpa
XP_002321221
480
54779
S431
V
D
R
E
A
L
S
S
L
G
L
T
S
G
V
Maize
Zea mays
NP_001150481
469
52213
L420
A
D
S
T
K
L
K
L
V
N
E
S
C
V
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
92.8
76.7
N.A.
73.4
73
N.A.
54.7
55.3
N.A.
46.1
N.A.
N.A.
N.A.
N.A.
37.1
Protein Similarity:
100
99.6
94.6
83.4
N.A.
81.1
80.7
N.A.
64.9
67.2
N.A.
60.2
N.A.
N.A.
N.A.
N.A.
49.4
P-Site Identity:
100
100
100
86.6
N.A.
60
66.6
N.A.
20
6.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
80
N.A.
20
20
N.A.
20
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
33.7
32.4
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
49.6
48.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
9
9
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
17
0
0
0
0
9
0
0
9
0
0
0
9
0
% D
% Glu:
9
0
0
17
0
9
0
17
25
9
9
0
0
0
9
% E
% Phe:
0
9
0
9
50
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
42
0
0
9
67
0
% G
% His:
0
0
0
0
0
0
0
0
0
9
25
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
9
0
0
0
0
0
0
9
% I
% Lys:
25
67
50
0
17
0
9
0
0
0
0
17
9
0
9
% K
% Leu:
0
0
0
0
0
25
0
9
9
0
9
0
9
0
17
% L
% Met:
50
0
0
9
0
9
9
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
9
0
0
9
34
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
25
0
42
42
9
0
0
% Q
% Arg:
0
0
17
0
9
50
0
0
0
9
0
17
9
0
0
% R
% Ser:
0
9
9
0
17
0
9
17
9
9
9
9
9
0
9
% S
% Thr:
0
0
0
9
0
0
0
0
9
0
0
9
0
0
42
% T
% Val:
9
0
9
50
0
0
50
0
9
0
0
0
0
25
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
17
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _