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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HERC5 All Species: 6.67
Human Site: T405 Identified Species: 14.67
UniProt: Q9UII4 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UII4 NP_057407.2 1024 116852 T405 R W I A D V E T K R W Q S T K
Chimpanzee Pan troglodytes XP_001160851 1020 115010 S397 W I A V K R R S T E H E M A K
Rhesus Macaque Macaca mulatta XP_001100859 1050 117053 D404 H Y T S L I N D E T I A V W R
Dog Lupus familis XP_535652 1157 130960 T538 R W I A D V G T K Q W Q N T K
Cat Felis silvestris
Mouse Mus musculus Q6PAV2 1057 118393 E404 K Q I W T V N E A L I Q K W L
Rat Rattus norvegicus Q5PQN1 1057 118521 E404 K Q I W T V N E A L I Q K W L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508293 996 112121 R393 D H Y R T G S R F S G V D M N
Chicken Gallus gallus XP_001231234 1056 118760 E404 K Q I W T V N E T F I Q R L L
Frog Xenopus laevis Q2TAS2 751 86306 E186 I T R T T Q W E R P T R P A S
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 P201 E Y S S P G R P L S C L V D E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 S328 L Y I N F Q F S R L L S N E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.2 35.3 67.7 N.A. 34.6 35 N.A. 36.5 35.4 20.3 21.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 65.7 54.9 75.8 N.A. 55.6 55.9 N.A. 57.4 56.1 37.9 37.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 0 80 N.A. 20 20 N.A. 0 20 0 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 33.3 93.3 N.A. 26.6 26.6 N.A. 0 26.6 13.3 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 19 0 0 0 0 19 0 0 10 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 10 0 0 0 19 0 0 10 0 0 0 0 10 10 0 % D
% Glu: 10 0 0 0 0 0 10 37 10 10 0 10 0 10 10 % E
% Phe: 0 0 0 0 10 0 10 0 10 10 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 19 10 0 0 0 10 0 0 0 0 % G
% His: 10 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 10 10 55 0 0 10 0 0 0 0 37 0 0 0 0 % I
% Lys: 28 0 0 0 10 0 0 0 19 0 0 0 19 0 28 % K
% Leu: 10 0 0 0 10 0 0 0 10 28 10 10 0 10 37 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 0 % M
% Asn: 0 0 0 10 0 0 37 0 0 0 0 0 19 0 10 % N
% Pro: 0 0 0 0 10 0 0 10 0 10 0 0 10 0 0 % P
% Gln: 0 28 0 0 0 19 0 0 0 10 0 46 0 0 0 % Q
% Arg: 19 0 10 10 0 10 19 10 19 10 0 10 10 0 10 % R
% Ser: 0 0 10 19 0 0 10 19 0 19 0 10 10 0 10 % S
% Thr: 0 10 10 10 46 0 0 19 19 10 10 0 0 19 0 % T
% Val: 0 0 0 10 0 46 0 0 0 0 0 10 19 0 0 % V
% Trp: 10 19 0 28 0 0 10 0 0 0 19 0 0 28 0 % W
% Tyr: 0 28 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _