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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
14.85
Human Site:
S295
Identified Species:
29.7
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S295
S
E
S
D
G
N
P
S
T
E
D
E
S
S
K
Chimpanzee
Pan troglodytes
XP_512758
709
71738
G229
R
R
Q
R
D
R
T
G
A
G
G
G
A
P
C
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
S294
S
E
S
D
G
N
P
S
T
E
D
E
S
S
K
Dog
Lupus familis
XP_547842
785
83131
S299
S
E
S
D
G
N
P
S
T
E
D
E
S
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
S288
S
E
S
D
G
N
P
S
T
E
D
E
S
S
K
Rat
Rattus norvegicus
NP_001100209
705
75711
K225
S
T
E
D
E
S
S
K
G
H
E
D
L
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
S30
P
S
T
E
D
E
S
S
K
G
H
E
D
L
S
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
NP_001089925
276
31231
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
L115
W
S
L
P
Q
S
D
L
L
R
G
N
E
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
A85
H
G
I
I
S
G
G
A
G
T
G
G
P
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
0
100
100
N.A.
100
20
N.A.
13.3
0
0
6.6
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
6.6
100
100
N.A.
100
40
N.A.
26.6
0
0
13.3
N.A.
0
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
9
9
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
0
0
0
42
17
0
9
0
0
0
34
9
9
0
0
% D
% Glu:
0
34
9
9
9
9
0
0
0
34
9
42
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
34
9
9
9
17
17
25
17
0
9
0
% G
% His:
9
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% H
% Ile:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
17
% I
% Lys:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
34
% K
% Leu:
0
0
9
0
0
0
0
9
9
0
0
0
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
34
0
0
0
0
0
9
0
0
0
% N
% Pro:
9
0
0
9
0
0
34
0
0
0
0
0
9
9
9
% P
% Gln:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
9
0
9
0
9
0
0
0
9
0
0
0
0
0
% R
% Ser:
42
17
34
0
9
17
17
42
0
0
0
0
34
50
9
% S
% Thr:
0
9
9
0
0
0
9
0
34
9
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _