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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM8
All Species:
12.73
Human Site:
S259
Identified Species:
17.5
UniProt:
Q9UJA3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UJA3
NP_115874.3
840
93697
S259
P
L
P
D
G
K
Y
S
L
P
T
K
C
P
V
Chimpanzee
Pan troglodytes
XP_001166964
840
93670
S259
P
L
P
D
G
K
Y
S
L
P
T
K
C
P
V
Rhesus Macaque
Macaca mulatta
XP_001115843
840
93650
S259
P
L
P
D
G
K
Y
S
L
P
T
K
C
P
V
Dog
Lupus familis
XP_534352
833
93150
C257
K
Y
N
L
P
T
K
C
P
V
P
T
C
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9CWV1
833
92353
P258
Y
T
L
P
T
K
C
P
V
P
A
C
R
G
R
Rat
Rattus norvegicus
NP_001099984
830
91958
A258
P
T
K
C
P
V
P
A
C
R
G
R
S
F
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514432
828
92086
F262
P
E
C
R
G
K
S
F
L
A
Q
R
S
S
P
Chicken
Gallus gallus
XP_001232579
830
92790
C260
T
K
C
L
V
P
E
C
R
G
R
S
F
T
P
Frog
Xenopus laevis
P55861
886
100243
E277
I
S
H
L
P
L
V
E
E
L
R
S
L
R
Q
Zebra Danio
Brachydanio rerio
XP_002665161
788
87122
D266
I
E
C
E
L
T
Q
D
L
V
D
S
C
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
S327
V
L
G
P
F
V
Q
S
Q
N
T
E
I
K
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34647
810
91112
T265
T
P
G
L
R
A
E
T
S
N
Q
N
R
G
R
Sea Urchin
Strong. purpuratus
XP_797782
848
93611
I259
H
L
P
N
G
K
Y
I
L
P
T
K
C
L
A
Poplar Tree
Populus trichocarpa
XP_002326332
745
82557
E227
L
Q
E
L
L
R
S
E
D
H
E
E
G
R
V
Maize
Zea mays
Q43704
768
85163
G250
K
S
K
G
S
V
S
G
V
F
R
T
V
L
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
L258
L
I
A
N
N
I
A
L
L
N
K
E
A
N
A
Baker's Yeast
Sacchar. cerevisiae
P53091
1017
112934
T328
V
E
Q
S
F
K
Y
T
E
P
T
F
C
P
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97
92.2
N.A.
89.2
89.7
N.A.
82.9
77.8
28.6
68.9
N.A.
25.8
N.A.
24.2
64.5
Protein Similarity:
100
99.8
98
95.8
N.A.
94.4
94
N.A.
90.5
87.2
47.2
80.8
N.A.
44.7
N.A.
43.6
77.1
P-Site Identity:
100
100
100
6.6
N.A.
13.3
6.6
N.A.
26.6
0
0
13.3
N.A.
20
N.A.
0
66.6
P-Site Similarity:
100
100
100
6.6
N.A.
20
20
N.A.
33.3
0
0
20
N.A.
26.6
N.A.
6.6
73.3
Percent
Protein Identity:
43.4
27.1
N.A.
27.7
25
N.A.
Protein Similarity:
61.3
48.6
N.A.
48.6
42.9
N.A.
P-Site Identity:
6.6
0
N.A.
6.6
40
N.A.
P-Site Similarity:
20
13.3
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
0
0
6
6
6
0
6
6
0
6
0
12
% A
% Cys:
0
0
18
6
0
0
6
12
6
0
0
6
42
0
0
% C
% Asp:
0
0
0
18
0
0
0
6
6
0
6
0
0
0
0
% D
% Glu:
0
18
6
6
0
0
12
12
12
0
6
18
0
0
0
% E
% Phe:
0
0
0
0
12
0
0
6
0
6
0
6
6
6
0
% F
% Gly:
0
0
12
6
30
0
0
6
0
6
6
0
6
12
6
% G
% His:
6
0
6
0
0
0
0
0
0
6
0
0
0
0
0
% H
% Ile:
12
6
0
0
0
6
0
6
0
0
0
0
6
0
6
% I
% Lys:
12
6
12
0
0
42
6
0
0
0
6
24
0
6
0
% K
% Leu:
12
30
6
30
12
6
0
6
42
6
0
0
6
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
6
12
6
0
0
0
0
18
0
6
0
6
6
% N
% Pro:
30
6
24
12
18
6
6
6
6
36
6
0
0
24
24
% P
% Gln:
0
6
6
0
0
0
12
0
6
0
12
0
0
0
6
% Q
% Arg:
0
0
0
6
6
6
0
0
6
6
18
12
12
18
12
% R
% Ser:
0
12
0
6
6
0
18
24
6
0
0
18
12
6
0
% S
% Thr:
12
12
0
0
6
12
0
12
0
0
36
12
0
6
6
% T
% Val:
12
0
0
0
6
18
6
0
12
12
0
0
6
6
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
6
0
0
0
0
30
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _